在进化的程度上看微核：对老问题的新见解

IF 4 2区生物学 Q2 CELL BIOLOGY

Journal of Cellular Physiology Pub Date : 2025-08-18 DOI:10.1002/jcp.70079

Shangzhi Yang, Haiyang Yao, Ying Zhang, Wenchuan Zhang, Shiqi Jin, Kainan Huang, Juan Song, Yan Feng, Xiaoguang Li, Xianli Wang

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引用次数: 0

摘要

微核（MNs），曾经被认为是细胞碎片或遗传毒性标记，也可以被认为是具有潜在进化意义的动态结构。在肿瘤模型中，MNs促进克隆多样化、诱变和适应性。MNs与保守的cGAS-STING通路的相互作用反映了个体免疫防御和细胞应激适应性反应的双重作用。MNs也可能与衰老相关的进化有关，并在胚胎发育中起作用。MN的存在和跨物种的功能表明MN能够提供基因组多样性和选择优势。因此，我们的理解是MN可能在生物体的整个生命过程中都有助于进化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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View Micronuclei in the Extent of Evolution: New Insight Into an Old Issue

Micronuclei (MNs), once regarded as cellular debris or genotoxicity markers, can also be recognized as dynamic structures with potential evolutionary significance. In tumor models, MNs promote clonal diversification, mutagenesis, and adaptation. MNs' interaction with the conserved cGAS-STING pathway reflects dual roles in immune defense for the individual and adaptive response for cell under stress. MNs may also contribute to aging-related evolution and be functional in embryonic development. MN's presence and function across species suggests the ability of MN to offer genomic diversity and selective advantage. Therefore, our understanding is that MN may contribute to evolution throughout life processes of organisms.

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来源期刊

Journal of Cellular Physiology 生物-生理学

CiteScore

14.70

自引率

0.00%

发文量

256

审稿时长

1 months

期刊介绍： The Journal of Cellular Physiology publishes reports of high biological significance in areas of eukaryotic cell biology and physiology, focusing on those articles that adopt a molecular mechanistic approach to investigate cell structure and function. There is appreciation for the application of cellular, biochemical, molecular and in vivo genetic approaches, as well as the power of genomics, proteomics, bioinformatics and systems biology. In particular, the Journal encourages submission of high-interest papers investigating the genetic and epigenetic regulation of proliferation and phenotype as well as cell fate and lineage commitment by growth factors, cytokines and their cognate receptors and signal transduction pathways that influence the expression, integration and activities of these physiological mediators. Similarly, the Journal encourages submission of manuscripts exploring the regulation of growth and differentiation by cell adhesion molecules in addition to the interplay between these processes and those induced by growth factors and cytokines. Studies on the genes and processes that regulate cell cycle progression and phase transition in eukaryotic cells, and the mechanisms that determine whether cells enter quiescence, proliferate or undergo apoptosis are also welcomed. Submission of papers that address contributions of the extracellular matrix to cellular phenotypes and physiological control as well as regulatory mechanisms governing fertilization, embryogenesis, gametogenesis, cell fate, lineage commitment, differentiation, development and dynamic parameters of cell motility are encouraged. Finally, the investigation of stem cells and changes that differentiate cancer cells from normal cells including studies on the properties and functions of oncogenes and tumor suppressor genes will remain as one of the major interests of the Journal.