糖尿病一级家族史与抑郁症状的存在相关,独立于生活方式危险因素和心脏代谢危险因素

IF 3.7 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Mengying Chen, Huimin Xia, Yaohui Yu, Yuhua Wang, Wei Chen, Enyu Lou, Zhezhe Tang, Lijuan Yang, Shengjie Ge, Bo Yang, Xuejiang Gu, Xiang Hu
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引用次数: 0

摘要

背景抑郁症和糖尿病的共存是精神-身体合并症的典型例子。本研究旨在探讨糖尿病一级家族史(FHD)与抑郁症状的关系。方法本工作是REACTION研究基线调查的一部分。一级FHD被定义为有一个或多个一级亲属患有糖尿病。采用患者健康问卷-9 (Patient Health Questionnaire-9)检测抑郁症状的存在,且其评分≥5分。进行逻辑回归分析以确定一级FHD与抑郁症状存在之间的关联。结果本研究共纳入4804名受试者。患有一级FHD的个体比没有一级FHD的个体更容易出现抑郁症状(7.2%对4.9%,p = 0.004)。调整性别、年龄、社会经济因素、生活方式危险因素、心脏代谢危险因素后,伴有一级FHD的患者抑郁症状的比值比(OR)增加49.8% (p = 0.007)。性别、年龄、各社会经济因素、生活方式危险因素和心脏代谢危险因素对一级FHD与抑郁症状存在的相关性没有显著的交互作用(p > 0.05)。结论一级FHD与抑郁症状相关,独立于社会经济因素、生活方式危险因素和心脏代谢危险因素。遗传背景可能是一级FHD患者抑郁症状家族聚集的主要原因,应尽早关注其心理健康状况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

First-Degree Family History of Diabetes Is Associated With the Presence of Depressive Symptoms Independent of Lifestyle Risk Factors and Cardiometabolic Risk Factors

First-Degree Family History of Diabetes Is Associated With the Presence of Depressive Symptoms Independent of Lifestyle Risk Factors and Cardiometabolic Risk Factors

Background

Co-occurrence of depression and diabetes is a prototypical example of mental-physical comorbidity. This study aims to investigate the association between first-degree family history of diabetes (FHD) and the presence of depressive symptoms.

Methods

The present work was one part of the baseline survey from the REACTION study. First-degree FHD was defined as having one or more first-degree relatives with diabetes. The Patient Health Questionnaire-9 was administered to detect the presence of depressive symptoms with its score ≥ 5. Logistic regression analyses were performed to determine the association between first-degree FHD and the presence of depressive symptoms.

Results

A total of 4804 participants were enrolled in the present study. Individuals with first-degree FHD were more likely to suffer from depressive symptoms compared with those without first-degree FHD (7.2% versus 4.9%, p = 0.004). The odds ratio (OR) of depressive symptoms was increased by 49.8% with the presence of first-degree FHD after adjustment of gender, age, socioeconomic factors, lifestyle risk factors, and cardiometabolic risk factors (p = 0.007). There were no significant interactions of gender, age, each socioeconomic factor, lifestyle risk factor, and cardiometabolic risk factors on the association between first-degree FHD and the presence of depressive symptoms, respectively (all p > 0.05).

Conclusions

First-degree FHD was associated with depressive symptoms independent of socioeconomic factors, lifestyle risk factors, and cardiometabolic risk factors. Genetic background might mainly contribute to the familial aggregation of depressive symptoms in individuals with first-degree FHD, who should be paid early attention to their mental health.

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来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
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