γ -谷氨酰转移酶与青少年代谢综合征及其成分之间的关系应用国际糖尿病联合会(IDF)和库克标准

IF 2.6 Q3 ENDOCRINOLOGY & METABOLISM
Farzad Esmaeili, Siavash Safiee, Mitra Hasheminia, Fereidoun Azizi, Maryam Tohidi, Farzad Hadaegh
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引用次数: 0

摘要

代谢综合征(MetS)是一组代谢异常,其患病率正在全球范围内上升,特别是在中东和北非。γ -谷氨酰转移酶(GGT)作为肝功能的生物标志物及其与MetS及其组分的关系正受到越来越多的关注。方法本横断面研究是德黑兰脂质和葡萄糖研究(TLGS)的一部分。我们纳入了第七次检查调查(2018-2021)中年龄在10-19岁的696名青少年(男性347名)。MetS的定义采用了国际糖尿病联合会(IDF)和库克的标准。测量血清GGT,并使用logistic回归评估其作为连续和分类变量的相关性,并对大量协变量进行调整。结果根据Cook's和IDF标准,met患病率分别为15.66%和9.19%。在调整年龄、性别、吸烟和2型糖尿病家族史后,根据两种定义,较高的GGT水平与met风险增加显著相关(比值比[95%置信区间]分别= 1.28[1.12-1.46]和1.30 [1.14-1.49]/ 5 U/L)。在调整ALT水平后,这种关联减弱。即使在调整谷丙转氨酶(ALT)后,每增加5 U/L, GGT水平与高腰围之间的比值比分别为1.98[1.59-2.46]和1.71[1.38-2.11]。与高血压(IDF和Cook标准增加21%和17%的风险)和甘油三酯(IDF和Cook标准增加13%和16%的风险)的关联显著,但在ALT调整后减弱。没有发现GGT水平与高空腹血糖或低高密度脂蛋白胆固醇之间的显著关联。结论:在青少年中,血清GGT升高与met及其组成部分的高风险密切相关,尤其是中心性肥胖。这些发现表明GGT是早期MetS检测的有价值的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Association Between Gamma-Glutamyl Transferase and Metabolic Syndrome and Its Components Among Adolescents Applying International Diabetes Federation (IDF) and Cook's Criteria

The Association Between Gamma-Glutamyl Transferase and Metabolic Syndrome and Its Components Among Adolescents Applying International Diabetes Federation (IDF) and Cook's Criteria

Introduction

The prevalence of metabolic syndrome (MetS), a cluster of metabolic abnormalities, is rising globally, particularly in the Middle East and North Africa. Gamma-glutamyl transferase (GGT) is gaining attention as a biomarker for liver function and its association with MetS and its components.

Methods

This cross-sectional study is part of the Tehran Lipid and Glucose Study (TLGS). We included 696 adolescents (347 males) aged 10–19 from the seventh examination survey (2018–2021). MetS was defined using both the International Diabetes Federation (IDF) and Cook's criteria. Serum GGT was measured, and its association as a continuous and categorical variable was assessed with MetS and its components using logistic regression, adjusting for a large set of covariates.

Results

MetS prevalence was 15.66% and 9.19% according to Cook's and IDF criteria, respectively. Higher GGT levels were significantly associated with increased MetS risk by both definitions (odds ratio [95% confidence interval] = 1.28 [1.12–1.46] and 1.30 [1.14–1.49] per 5 U/L increase, respectively) after adjusting for age, sex, smoking and family history of type 2 diabetes mellitus. This association was attenuated upon adjusting for ALT levels. GGT levels were robustly associated with high waist circumference, with odds ratios of 1.98 [1.59–2.46] and 1.71 [1.38–2.11] per 5 U/L increase, respectively, even after adjusting for alanine aminotransferase (ALT). Associations with high blood pressure (21% and 17% increased risk by IDF and Cook's criteria) and triglycerides (13% and 16% increased risk by IDF and Cook's criteria) were significant but attenuated after ALT adjustment. No significant associations were found between GGT levels and high fasting plasma glucose or low high-density lipoprotein cholesterol.

Conclusions

Elevated serum GGT is strongly associated with a higher risk of MetS and its components, particularly central obesity, in adolescents. These findings suggest that GGT is a valuable biomarker for early MetS detection.

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来源期刊
Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.00
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0.00%
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66
审稿时长
6 weeks
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