Hongmei Du , Cui Cui , Tianhao Zhang , Quan Cai , Yijie Zhang , Haijia Hou
{"title":"黄芩苷纳米颗粒在传统植物药物抗病毒治疗中的传递和药效学增强机制研究","authors":"Hongmei Du , Cui Cui , Tianhao Zhang , Quan Cai , Yijie Zhang , Haijia Hou","doi":"10.1016/j.indcrop.2025.121690","DOIUrl":null,"url":null,"abstract":"<div><div>Baicalin, a major flavonoid extracted from <em>Scutellaria baicalensis</em>, exhibits strong antiviral, anti-inflammatory, and immunomodulatory properties widely recognized in Traditional Chinese Medicine (TCM). Despite its therapeutic potential, baicalin’s clinical efficacy is limited by its poor solubility, low bioavailability, and rapid metabolism. Recent advances in nanotechnology have enabled the development of baicalin-loaded nanoparticles to overcome these challenges and enhance pharmacodynamic performance. This review provides mechanistic insights into the delivery systems of baicalin nanoparticles, including their design, cellular uptake pathways, and biological interactions that promote targeted and sustained drug release. We discuss how nanoformulations improve pharmacokinetics, enhance antiviral efficacy, and synergize with other TCM-based compounds. Preclinical evidence is examined along with the translational potential of baicalin nanoparticles, which highlight the technical challenges, regulatory issues, and safety barriers. In addition, we discuss issues related to clinical confirmation of these nanocarriers and integrated treatment strategies while suggesting future directions for optimizing recent nanotechnology with TCM antiviral strategies. By combining modern nanocarrier systems with traditional herbal medicine, baicalin nanoparticles represent a promising frontier in innovative antiviral drug development.</div></div>","PeriodicalId":13581,"journal":{"name":"Industrial Crops and Products","volume":"235 ","pages":"Article 121690"},"PeriodicalIF":6.2000,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mechanistic insights into the delivery and pharmacodynamic enhancement of baicalin nanoparticles in traditional chinese plant medicine-based antiviral therapies\",\"authors\":\"Hongmei Du , Cui Cui , Tianhao Zhang , Quan Cai , Yijie Zhang , Haijia Hou\",\"doi\":\"10.1016/j.indcrop.2025.121690\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Baicalin, a major flavonoid extracted from <em>Scutellaria baicalensis</em>, exhibits strong antiviral, anti-inflammatory, and immunomodulatory properties widely recognized in Traditional Chinese Medicine (TCM). Despite its therapeutic potential, baicalin’s clinical efficacy is limited by its poor solubility, low bioavailability, and rapid metabolism. Recent advances in nanotechnology have enabled the development of baicalin-loaded nanoparticles to overcome these challenges and enhance pharmacodynamic performance. This review provides mechanistic insights into the delivery systems of baicalin nanoparticles, including their design, cellular uptake pathways, and biological interactions that promote targeted and sustained drug release. We discuss how nanoformulations improve pharmacokinetics, enhance antiviral efficacy, and synergize with other TCM-based compounds. Preclinical evidence is examined along with the translational potential of baicalin nanoparticles, which highlight the technical challenges, regulatory issues, and safety barriers. In addition, we discuss issues related to clinical confirmation of these nanocarriers and integrated treatment strategies while suggesting future directions for optimizing recent nanotechnology with TCM antiviral strategies. By combining modern nanocarrier systems with traditional herbal medicine, baicalin nanoparticles represent a promising frontier in innovative antiviral drug development.</div></div>\",\"PeriodicalId\":13581,\"journal\":{\"name\":\"Industrial Crops and Products\",\"volume\":\"235 \",\"pages\":\"Article 121690\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2025-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Industrial Crops and Products\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0926669025012361\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURAL ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Industrial Crops and Products","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0926669025012361","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURAL ENGINEERING","Score":null,"Total":0}
Mechanistic insights into the delivery and pharmacodynamic enhancement of baicalin nanoparticles in traditional chinese plant medicine-based antiviral therapies
Baicalin, a major flavonoid extracted from Scutellaria baicalensis, exhibits strong antiviral, anti-inflammatory, and immunomodulatory properties widely recognized in Traditional Chinese Medicine (TCM). Despite its therapeutic potential, baicalin’s clinical efficacy is limited by its poor solubility, low bioavailability, and rapid metabolism. Recent advances in nanotechnology have enabled the development of baicalin-loaded nanoparticles to overcome these challenges and enhance pharmacodynamic performance. This review provides mechanistic insights into the delivery systems of baicalin nanoparticles, including their design, cellular uptake pathways, and biological interactions that promote targeted and sustained drug release. We discuss how nanoformulations improve pharmacokinetics, enhance antiviral efficacy, and synergize with other TCM-based compounds. Preclinical evidence is examined along with the translational potential of baicalin nanoparticles, which highlight the technical challenges, regulatory issues, and safety barriers. In addition, we discuss issues related to clinical confirmation of these nanocarriers and integrated treatment strategies while suggesting future directions for optimizing recent nanotechnology with TCM antiviral strategies. By combining modern nanocarrier systems with traditional herbal medicine, baicalin nanoparticles represent a promising frontier in innovative antiviral drug development.
期刊介绍:
Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.