黄芩苷纳米颗粒在传统植物药物抗病毒治疗中的传递和药效学增强机制研究

IF 6.2 1区 农林科学 Q1 AGRICULTURAL ENGINEERING
Hongmei Du , Cui Cui , Tianhao Zhang , Quan Cai , Yijie Zhang , Haijia Hou
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引用次数: 0

摘要

黄芩苷是从黄芩中提取的一种主要类黄酮,具有很强的抗病毒、抗炎和免疫调节作用,在中药中得到广泛认可。尽管黄芩苷具有治疗潜力,但其溶解度差、生物利用度低、代谢快,限制了其临床疗效。纳米技术的最新进展使装载黄芩苷的纳米颗粒的开发能够克服这些挑战并提高药效学性能。本文综述了黄芩苷纳米颗粒递送系统的机理,包括它们的设计、细胞摄取途径和促进靶向和持续药物释放的生物相互作用。我们讨论了纳米制剂如何改善药代动力学,增强抗病毒功效,并与其他中药化合物协同作用。临床前证据与黄芩苷纳米颗粒的转化潜力一起进行了检查,其中突出了技术挑战,监管问题和安全障碍。此外,我们还讨论了与这些纳米载体的临床证实和综合治疗策略相关的问题,并提出了优化现有纳米技术与中医药抗病毒策略的未来方向。通过将现代纳米载体系统与传统草药相结合,黄芩苷纳米颗粒代表了创新抗病毒药物开发的一个有前景的前沿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanistic insights into the delivery and pharmacodynamic enhancement of baicalin nanoparticles in traditional chinese plant medicine-based antiviral therapies
Baicalin, a major flavonoid extracted from Scutellaria baicalensis, exhibits strong antiviral, anti-inflammatory, and immunomodulatory properties widely recognized in Traditional Chinese Medicine (TCM). Despite its therapeutic potential, baicalin’s clinical efficacy is limited by its poor solubility, low bioavailability, and rapid metabolism. Recent advances in nanotechnology have enabled the development of baicalin-loaded nanoparticles to overcome these challenges and enhance pharmacodynamic performance. This review provides mechanistic insights into the delivery systems of baicalin nanoparticles, including their design, cellular uptake pathways, and biological interactions that promote targeted and sustained drug release. We discuss how nanoformulations improve pharmacokinetics, enhance antiviral efficacy, and synergize with other TCM-based compounds. Preclinical evidence is examined along with the translational potential of baicalin nanoparticles, which highlight the technical challenges, regulatory issues, and safety barriers. In addition, we discuss issues related to clinical confirmation of these nanocarriers and integrated treatment strategies while suggesting future directions for optimizing recent nanotechnology with TCM antiviral strategies. By combining modern nanocarrier systems with traditional herbal medicine, baicalin nanoparticles represent a promising frontier in innovative antiviral drug development.
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来源期刊
Industrial Crops and Products
Industrial Crops and Products 农林科学-农业工程
CiteScore
9.50
自引率
8.50%
发文量
1518
审稿时长
43 days
期刊介绍: Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.
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