小脑-前额叶连通性预测精神病谱系中负面症状的严重程度。

IF 4.8
Sean A Yarrell, Sophia H Blyth, Alexandra B Moussa-Tooks, Baxter P Rogers, Anna Huang, Neil D Woodward, Stephan Heckers, Roscoe O Brady, Heather Burrell Ward
{"title":"小脑-前额叶连通性预测精神病谱系中负面症状的严重程度。","authors":"Sean A Yarrell, Sophia H Blyth, Alexandra B Moussa-Tooks, Baxter P Rogers, Anna Huang, Neil D Woodward, Stephan Heckers, Roscoe O Brady, Heather Burrell Ward","doi":"10.1016/j.bpsc.2025.07.013","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Negative symptom severity predicts functional outcome and quality of life in people with psychosis. However, negative symptoms are poorly responsive to medication, and existing literature has not converged on their neurobiological basis. Previous work in small schizophrenia samples has observed that lower cerebellar-dorsolateral prefrontal cortex (DLPFC) connectivity is associated with higher negative symptom severity and that increasing cerebellar-DLPFC connectivity with neuromodulation reduces negative symptoms. We extended this finding by testing associations between cerebellar-DLPFC connectivity, negative symptoms, and cognitive performance in a large sample of individuals with psychosis.</p><p><strong>Methods: </strong>Individuals with psychosis spectrum disorders (n=260) underwent resting-state fMRI and clinical characterization using the Positive and Negative Symptoms Scale and the Screen for Cognitive Impairment in Psychiatry. Using a previously identified cerebellar region as a seed, we measured connectivity to the DLPFC and regressed connectivity against negative symptom severity, covarying for age, sex, and scanner. We then tested if cognitive performance indirectly affected the relationship between connectivity and negative symptom severity.</p><p><strong>Results: </strong>Across the psychosis spectrum, higher cerebellar-DLPFC connectivity was associated with lower negative symptom severity (r=-0.17, p=.007). This connectivity-negative symptoms relationship was not affected by psychosis subtype or duration of illness. Better delayed verbal learning was associated with higher cerebellar-DLPFC connectivity (r=.13, p=.034) and had a significant indirect effect on the relationship between connectivity and negative symptoms.</p><p><strong>Conclusions: </strong>Our results extend relationships between cerebellar-DLPFC connectivity, negative symptom severity, and cognitive performance across the psychosis spectrum. Larger neuromodulation studies should test if increasing cerebellar-DLPFC connectivity reduces negative symptoms in psychotic disorders.</p>","PeriodicalId":93900,"journal":{"name":"Biological psychiatry. Cognitive neuroscience and neuroimaging","volume":" ","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum.\",\"authors\":\"Sean A Yarrell, Sophia H Blyth, Alexandra B Moussa-Tooks, Baxter P Rogers, Anna Huang, Neil D Woodward, Stephan Heckers, Roscoe O Brady, Heather Burrell Ward\",\"doi\":\"10.1016/j.bpsc.2025.07.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Negative symptom severity predicts functional outcome and quality of life in people with psychosis. However, negative symptoms are poorly responsive to medication, and existing literature has not converged on their neurobiological basis. Previous work in small schizophrenia samples has observed that lower cerebellar-dorsolateral prefrontal cortex (DLPFC) connectivity is associated with higher negative symptom severity and that increasing cerebellar-DLPFC connectivity with neuromodulation reduces negative symptoms. We extended this finding by testing associations between cerebellar-DLPFC connectivity, negative symptoms, and cognitive performance in a large sample of individuals with psychosis.</p><p><strong>Methods: </strong>Individuals with psychosis spectrum disorders (n=260) underwent resting-state fMRI and clinical characterization using the Positive and Negative Symptoms Scale and the Screen for Cognitive Impairment in Psychiatry. Using a previously identified cerebellar region as a seed, we measured connectivity to the DLPFC and regressed connectivity against negative symptom severity, covarying for age, sex, and scanner. We then tested if cognitive performance indirectly affected the relationship between connectivity and negative symptom severity.</p><p><strong>Results: </strong>Across the psychosis spectrum, higher cerebellar-DLPFC connectivity was associated with lower negative symptom severity (r=-0.17, p=.007). This connectivity-negative symptoms relationship was not affected by psychosis subtype or duration of illness. Better delayed verbal learning was associated with higher cerebellar-DLPFC connectivity (r=.13, p=.034) and had a significant indirect effect on the relationship between connectivity and negative symptoms.</p><p><strong>Conclusions: </strong>Our results extend relationships between cerebellar-DLPFC connectivity, negative symptom severity, and cognitive performance across the psychosis spectrum. Larger neuromodulation studies should test if increasing cerebellar-DLPFC connectivity reduces negative symptoms in psychotic disorders.</p>\",\"PeriodicalId\":93900,\"journal\":{\"name\":\"Biological psychiatry. Cognitive neuroscience and neuroimaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological psychiatry. Cognitive neuroscience and neuroimaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.bpsc.2025.07.013\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological psychiatry. Cognitive neuroscience and neuroimaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.bpsc.2025.07.013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:负性症状严重程度可预测精神病患者的功能结局和生活质量。然而,阴性症状对药物的反应较差,现有文献尚未在其神经生物学基础上融合。先前对精神分裂症小样本的研究发现,较低的小脑-背外侧前额叶皮层(DLPFC)连通性与较高的阴性症状严重程度相关,而增加的小脑-DLPFC连通性与神经调节可以减轻阴性症状。我们通过在大量精神病患者样本中测试小脑- dlpfc连接、阴性症状和认知表现之间的关联来扩展这一发现。方法:精神病谱系障碍患者(n=260)接受静息状态功能磁共振成像,并使用阳性和阴性症状量表和精神病学认知障碍筛查进行临床表征。使用先前确定的小脑区域作为种子,我们测量了与DLPFC的连通性,并根据年龄、性别和扫描仪共变的负面症状严重程度对连通性进行了回归。然后,我们测试了认知表现是否间接影响连通性和负面症状严重程度之间的关系。结果:在整个精神病谱系中,小脑- dlpfc连接性越高,阴性症状严重程度越低(r=-0.17, p=.007)。这种连通性-阴性症状关系不受精神病亚型或疾病持续时间的影响。较好的延迟语言学习与较高的小脑- dlpfc连通性相关(r=)。13, p= 0.034),并且对连通性与阴性症状之间的关系有显著的间接影响。结论:我们的研究结果扩展了小脑- dlpfc连通性、负面症状严重程度和整个精神病谱系的认知表现之间的关系。更大规模的神经调节研究应该测试增加小脑- dlpfc连通性是否会减少精神障碍的阴性症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum.

Background: Negative symptom severity predicts functional outcome and quality of life in people with psychosis. However, negative symptoms are poorly responsive to medication, and existing literature has not converged on their neurobiological basis. Previous work in small schizophrenia samples has observed that lower cerebellar-dorsolateral prefrontal cortex (DLPFC) connectivity is associated with higher negative symptom severity and that increasing cerebellar-DLPFC connectivity with neuromodulation reduces negative symptoms. We extended this finding by testing associations between cerebellar-DLPFC connectivity, negative symptoms, and cognitive performance in a large sample of individuals with psychosis.

Methods: Individuals with psychosis spectrum disorders (n=260) underwent resting-state fMRI and clinical characterization using the Positive and Negative Symptoms Scale and the Screen for Cognitive Impairment in Psychiatry. Using a previously identified cerebellar region as a seed, we measured connectivity to the DLPFC and regressed connectivity against negative symptom severity, covarying for age, sex, and scanner. We then tested if cognitive performance indirectly affected the relationship between connectivity and negative symptom severity.

Results: Across the psychosis spectrum, higher cerebellar-DLPFC connectivity was associated with lower negative symptom severity (r=-0.17, p=.007). This connectivity-negative symptoms relationship was not affected by psychosis subtype or duration of illness. Better delayed verbal learning was associated with higher cerebellar-DLPFC connectivity (r=.13, p=.034) and had a significant indirect effect on the relationship between connectivity and negative symptoms.

Conclusions: Our results extend relationships between cerebellar-DLPFC connectivity, negative symptom severity, and cognitive performance across the psychosis spectrum. Larger neuromodulation studies should test if increasing cerebellar-DLPFC connectivity reduces negative symptoms in psychotic disorders.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信