2023-24年冬季英国卫生保健工作者流感疫苗预防感染的有效性：SIREN队列研究

IF 11.9 1区医学 Q1 INFECTIOUS DISEASES

Journal of Infection Pub Date : 2025-08-13 DOI:10.1016/j.jinf.2025.106585

Luke J. McGeoch , Sarah Foulkes , Heather Whitaker , Katie Munro , Jameel Khawam , Dominic Sparkes , Andre Charlett , Colin S. Brown , Ana Atti , Jasmin Islam , Susan Hopkins , Nick Andrews , Victoria J. Hall

{"title":"2023-24年冬季英国卫生保健工作者流感疫苗预防感染的有效性：SIREN队列研究","authors":"Luke J. McGeoch , Sarah Foulkes , Heather Whitaker , Katie Munro , Jameel Khawam , Dominic Sparkes , Andre Charlett , Colin S. Brown , Ana Atti , Jasmin Islam , Susan Hopkins , Nick Andrews , Victoria J. Hall","doi":"10.1016/j.jinf.2025.106585","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>To determine vaccine effectiveness against influenza infection among UK healthcare workers between 1 September 2023 and 31 March 2024.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study, including hospital-based healthcare workers (HCWs) enrolled in the SARS-CoV-2 Immunity & Reinfection Evaluation (SIREN) study. Participants completed fortnightly influenza PCR testing and questionnaires. Influenza vaccination status was identified from national vaccination records and questionnaires. Vaccine effectiveness against PCR-positive influenza was estimated using Cox regression adjusted for age group, sex, chronic disease status, patient-facing role, and region. Case-control and test-negative case-control (TNCC) analyses, using multivariable logistic regression, were also performed.</div></div><div><h3>Results</h3><div>Among 4934 participants, median age was 55 years (IQR 47–60 years) and most were female (78.7%) and white (85.6%). Overall, 3857 (78.2%) received influenza vaccination and 266 (5.4%) tested positive for influenza, of which 227 (85.3%) reported acute respiratory infection symptoms. Adjusted vaccine effectiveness was 39.9% (95% confidence interval 21.8 – 53.8), and similar using case-control (41.2%, 22.5 – 55.2) and TNCC (45.9%, 21.8 – 62.2) approaches.</div></div><div><h3>Conclusions</h3><div>Influenza vaccine effectiveness was 40%, consistent with estimates for symptomatic patients. Applied to the combined UK healthcare workforce, this potentially translates to prevention of over 50,000 infections. These findings emphasise the importance of seasonal influenza vaccination to reduce healthcare workers infections and thereby protect patients and reduce workforce pressures.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 3","pages":"Article 106585"},"PeriodicalIF":11.9000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of influenza vaccination against infection in UK healthcare workers during winter 2023-24: The SIREN cohort study\",\"authors\":\"Luke J. McGeoch , Sarah Foulkes , Heather Whitaker , Katie Munro , Jameel Khawam , Dominic Sparkes , Andre Charlett , Colin S. Brown , Ana Atti , Jasmin Islam , Susan Hopkins , Nick Andrews , Victoria J. Hall\",\"doi\":\"10.1016/j.jinf.2025.106585\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>To determine vaccine effectiveness against influenza infection among UK healthcare workers between 1 September 2023 and 31 March 2024.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study, including hospital-based healthcare workers (HCWs) enrolled in the SARS-CoV-2 Immunity & Reinfection Evaluation (SIREN) study. Participants completed fortnightly influenza PCR testing and questionnaires. Influenza vaccination status was identified from national vaccination records and questionnaires. Vaccine effectiveness against PCR-positive influenza was estimated using Cox regression adjusted for age group, sex, chronic disease status, patient-facing role, and region. Case-control and test-negative case-control (TNCC) analyses, using multivariable logistic regression, were also performed.</div></div><div><h3>Results</h3><div>Among 4934 participants, median age was 55 years (IQR 47–60 years) and most were female (78.7%) and white (85.6%). Overall, 3857 (78.2%) received influenza vaccination and 266 (5.4%) tested positive for influenza, of which 227 (85.3%) reported acute respiratory infection symptoms. Adjusted vaccine effectiveness was 39.9% (95% confidence interval 21.8 – 53.8), and similar using case-control (41.2%, 22.5 – 55.2) and TNCC (45.9%, 21.8 – 62.2) approaches.</div></div><div><h3>Conclusions</h3><div>Influenza vaccine effectiveness was 40%, consistent with estimates for symptomatic patients. Applied to the combined UK healthcare workforce, this potentially translates to prevention of over 50,000 infections. These findings emphasise the importance of seasonal influenza vaccination to reduce healthcare workers infections and thereby protect patients and reduce workforce pressures.</div></div>\",\"PeriodicalId\":50180,\"journal\":{\"name\":\"Journal of Infection\",\"volume\":\"91 3\",\"pages\":\"Article 106585\"},\"PeriodicalIF\":11.9000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Infection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0163445325001859\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0163445325001859","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

目的：确定2023年9月1日至2024年3月31日期间英国卫生保健工作者中预防流感感染的疫苗有效性。方法：我们进行了一项前瞻性队列研究，包括参加SARS-CoV-2免疫和再感染评估（SIREN）研究的医院医护人员（HCWs）。参与者每两周完成一次流感PCR检测和问卷调查。通过国家疫苗接种记录和问卷调查确定流感疫苗接种状况。采用Cox回归对年龄、性别、慢性疾病状态、患者面对角色和地区进行校正，估计疫苗对pcr阳性流感的有效性。采用多变量logistic回归进行病例对照和检测阴性病例对照（TNCC）分析。结果：4934名参与者中位年龄为55岁（IQR 47-60岁），以女性（78.7%）和白人（85.6%）居多。总体而言，3,857人（78.2%）接受了流感疫苗接种，266人（5.4%）的流感检测呈阳性，其中227人（85.3%）报告了急性呼吸道感染症状。调整后的疫苗有效性为39.9%(95%置信区间为21.8 - 53.8)，采用病例对照（41.2%,22.5 - 55.2）和TNCC（45.9%, 21.8 - 62.2）方法相似。结论：流感疫苗的有效性为40%，与对有症状患者的估计一致。应用于联合英国医疗保健劳动力，这可能转化为预防超过50,000例感染。这些发现强调了季节性流感疫苗接种对减少卫生保健工作者感染的重要性，从而保护患者并减少劳动力压力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effectiveness of influenza vaccination against infection in UK healthcare workers during winter 2023-24: The SIREN cohort study

Objectives

To determine vaccine effectiveness against influenza infection among UK healthcare workers between 1 September 2023 and 31 March 2024.

Methods

We conducted a prospective cohort study, including hospital-based healthcare workers (HCWs) enrolled in the SARS-CoV-2 Immunity & Reinfection Evaluation (SIREN) study. Participants completed fortnightly influenza PCR testing and questionnaires. Influenza vaccination status was identified from national vaccination records and questionnaires. Vaccine effectiveness against PCR-positive influenza was estimated using Cox regression adjusted for age group, sex, chronic disease status, patient-facing role, and region. Case-control and test-negative case-control (TNCC) analyses, using multivariable logistic regression, were also performed.

Results

Among 4934 participants, median age was 55 years (IQR 47–60 years) and most were female (78.7%) and white (85.6%). Overall, 3857 (78.2%) received influenza vaccination and 266 (5.4%) tested positive for influenza, of which 227 (85.3%) reported acute respiratory infection symptoms. Adjusted vaccine effectiveness was 39.9% (95% confidence interval 21.8 – 53.8), and similar using case-control (41.2%, 22.5 – 55.2) and TNCC (45.9%, 21.8 – 62.2) approaches.

Conclusions

Influenza vaccine effectiveness was 40%, consistent with estimates for symptomatic patients. Applied to the combined UK healthcare workforce, this potentially translates to prevention of over 50,000 infections. These findings emphasise the importance of seasonal influenza vaccination to reduce healthcare workers infections and thereby protect patients and reduce workforce pressures.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Infection 医学-传染病学

CiteScore

45.90

自引率

3.20%

发文量

475

审稿时长

16 days

期刊介绍： The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.