提防宿主对噬菌体的免疫反应可能影响噬菌体治疗。

IF 3.5 1区农林科学 Q1 VETERINARY SCIENCES

Veterinary Research Pub Date : 2025-08-15 DOI:10.1186/s13567-025-01600-1

Thomas Démoulins, Jérémy D R Cherbuin, Thatcha Yimthin, Lukas Eggerschwiler, Fazal Adnan, Joerg Jores

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引用次数: 0

摘要

抗菌素耐药性的日益蔓延给动物福利、生产力和不同牲畜物种的食物供应带来了细菌感染方面的挑战。噬菌体提供了控制耐药细菌感染的替代方法。本研究研究了宿主对裂解噬菌体K和T1的免疫反应，分别作用于革兰氏阳性和革兰氏阴性细菌。我们利用一个离体平台来破译八头远交种牛的原代血细胞引发的各种免疫反应。噬菌体K未被识别，而噬菌体T1诱导了深刻的免疫反应。因此，在治疗开始前，应考虑宿主对治疗性噬菌体的免疫反应的预先表征。

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Beware of host immune responses towards bacteriophages potentially impacting phage therapy.

The rising spread of antimicrobial resistance challenges animal welfare, productivity and food supply with respect to bacterial infections in different livestock species. Bacteriophages offer alternative means to control infections with resistant bacteria. This work investigated the host immune responses towards lytic bacteriophages K and T1, acting respectively on Gram-positive or Gram-negative bacteria. We employed an ex vivo platform to decipher various immune responses elicited by primary blood cells of eight outbred cattle. Bacteriophage K was not recognized whereas bacteriophage T1 induced a profound immune response. Therefore, prior characterization of host immune responses towards therapeutic phages should be considered before therapy starts.

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来源期刊

Veterinary Research 农林科学-兽医学

CiteScore

7.00

自引率

4.50%

发文量

审稿时长

3 months

期刊介绍： Veterinary Research is an open access journal that publishes high quality and novel research and review articles focusing on all aspects of infectious diseases and host-pathogen interaction in animals.