Daniel Cantré, Lars Gerigk, Simon David Sprengel, Christian Plathow, Iris Burkholder, Marc-André Weber, Anna Schedler, Christoph Rehnitz
{"title":"计算机断层扫描引导下神经根周围浸润和小关节浸润的多中心前瞻性研究。","authors":"Daniel Cantré, Lars Gerigk, Simon David Sprengel, Christian Plathow, Iris Burkholder, Marc-André Weber, Anna Schedler, Christoph Rehnitz","doi":"10.1007/s00234-025-03741-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Evaluation of the success of periradicular infiltration and facet joint infiltration in a multicenter and prospective approach.</p><p><strong>Materials and methods: </strong>114 patients undergoing therapeutic nerve root or facet joint infiltration for radicular and/or facet joint symptoms between the first lumbar and the first sacral segments were prospectively and consecutively enrolled across nine participating study centers in Germany. These centers provide CT-guided pain procedures continuously over a period of 96 months. Assessment was carried out by means of a systematic patient survey including pain questionnaires. The severity of the pain and the impairment caused by pain were assessed using 11-point Numerical Rating Scales.</p><p><strong>Results: </strong>CT-guided periradicular infiltration and facet joint infiltration significantly reduced pain levels and substantially reduced pain frequency at all time points and up to three months after the last intervention. All pain related characteristics (i.e. actual pain, average pain level, maximum pain level) were significantly (95% confidence intervals (CI) ranging between - 1.0 and - 5.0) reduced at all time points when compared to the baseline. Besides the pure pain levels, the presented data also provide detailed insights into the complex associated issues the patient collective is facing including impairment in everyday life, fitness for work and leisure time activities. These parameters were also substantially improved (95% CI between - 0.0 and - 5.0) at all time points indicating a comprehensive patient benefit. Self-reported patient satisfaction, recommendation of the procedure and personal success were rated high (62-100%). The rate of patients on sick leave dropped from 23.7 to 1.9%. Accordingly, patients reported a high rate of satisfaction with the procedures. There was a high technical and clinical success rate with no major complications.</p><p><strong>Conclusion: </strong>CT-guided pain therapy on the lumbar spine is effective and safe with a comprehensive benefit for patients, including not only pain levels in the narrow meaning but also regarding everyday life, fitness for work and leisure time activities at all investigated time points including 3 months follow-up.</p>","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multicentric prospective study on computed tomography-guided periradicular infiltration and facet joint infiltration.\",\"authors\":\"Daniel Cantré, Lars Gerigk, Simon David Sprengel, Christian Plathow, Iris Burkholder, Marc-André Weber, Anna Schedler, Christoph Rehnitz\",\"doi\":\"10.1007/s00234-025-03741-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Evaluation of the success of periradicular infiltration and facet joint infiltration in a multicenter and prospective approach.</p><p><strong>Materials and methods: </strong>114 patients undergoing therapeutic nerve root or facet joint infiltration for radicular and/or facet joint symptoms between the first lumbar and the first sacral segments were prospectively and consecutively enrolled across nine participating study centers in Germany. These centers provide CT-guided pain procedures continuously over a period of 96 months. Assessment was carried out by means of a systematic patient survey including pain questionnaires. The severity of the pain and the impairment caused by pain were assessed using 11-point Numerical Rating Scales.</p><p><strong>Results: </strong>CT-guided periradicular infiltration and facet joint infiltration significantly reduced pain levels and substantially reduced pain frequency at all time points and up to three months after the last intervention. All pain related characteristics (i.e. actual pain, average pain level, maximum pain level) were significantly (95% confidence intervals (CI) ranging between - 1.0 and - 5.0) reduced at all time points when compared to the baseline. Besides the pure pain levels, the presented data also provide detailed insights into the complex associated issues the patient collective is facing including impairment in everyday life, fitness for work and leisure time activities. These parameters were also substantially improved (95% CI between - 0.0 and - 5.0) at all time points indicating a comprehensive patient benefit. Self-reported patient satisfaction, recommendation of the procedure and personal success were rated high (62-100%). The rate of patients on sick leave dropped from 23.7 to 1.9%. Accordingly, patients reported a high rate of satisfaction with the procedures. There was a high technical and clinical success rate with no major complications.</p><p><strong>Conclusion: </strong>CT-guided pain therapy on the lumbar spine is effective and safe with a comprehensive benefit for patients, including not only pain levels in the narrow meaning but also regarding everyday life, fitness for work and leisure time activities at all investigated time points including 3 months follow-up.</p>\",\"PeriodicalId\":19422,\"journal\":{\"name\":\"Neuroradiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroradiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00234-025-03741-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-025-03741-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Multicentric prospective study on computed tomography-guided periradicular infiltration and facet joint infiltration.
Purpose: Evaluation of the success of periradicular infiltration and facet joint infiltration in a multicenter and prospective approach.
Materials and methods: 114 patients undergoing therapeutic nerve root or facet joint infiltration for radicular and/or facet joint symptoms between the first lumbar and the first sacral segments were prospectively and consecutively enrolled across nine participating study centers in Germany. These centers provide CT-guided pain procedures continuously over a period of 96 months. Assessment was carried out by means of a systematic patient survey including pain questionnaires. The severity of the pain and the impairment caused by pain were assessed using 11-point Numerical Rating Scales.
Results: CT-guided periradicular infiltration and facet joint infiltration significantly reduced pain levels and substantially reduced pain frequency at all time points and up to three months after the last intervention. All pain related characteristics (i.e. actual pain, average pain level, maximum pain level) were significantly (95% confidence intervals (CI) ranging between - 1.0 and - 5.0) reduced at all time points when compared to the baseline. Besides the pure pain levels, the presented data also provide detailed insights into the complex associated issues the patient collective is facing including impairment in everyday life, fitness for work and leisure time activities. These parameters were also substantially improved (95% CI between - 0.0 and - 5.0) at all time points indicating a comprehensive patient benefit. Self-reported patient satisfaction, recommendation of the procedure and personal success were rated high (62-100%). The rate of patients on sick leave dropped from 23.7 to 1.9%. Accordingly, patients reported a high rate of satisfaction with the procedures. There was a high technical and clinical success rate with no major complications.
Conclusion: CT-guided pain therapy on the lumbar spine is effective and safe with a comprehensive benefit for patients, including not only pain levels in the narrow meaning but also regarding everyday life, fitness for work and leisure time activities at all investigated time points including 3 months follow-up.
期刊介绍:
Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.