芙蓉花提取物介导氧化锌纳米颗粒的制备、表征及其抑菌活性

Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-08-09 DOI:10.1016/j.prmcm.2025.100673

Komal Thakur , Avneet Kaur

{"title":"芙蓉花提取物介导氧化锌纳米颗粒的制备、表征及其抑菌活性","authors":"Komal Thakur , Avneet Kaur","doi":"10.1016/j.prmcm.2025.100673","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div><em>Hibiscus rosa-sinensis</em> commonly known as Zhū Jǐn Huā' (朱槿花) which is widely beings used in Traditional Chinese Medicine (TCM) in the form of herbal preparations and decoctions for the ailment of inflammations, skin infections, and gynecological disorders. Zhū Jǐn Huā' (朱槿花) is well known for its good phytochemicals composition including anthocyanins, flavonoids and other bioactive components making it a promising choice for linking traditional Chinese medical knowledge with modern nanotechnology.</div></div><div><h3>Method</h3><div>ZnO NPs (Zinc oxide nanoparticles) were fabricated following simple chemical precipitation method using aqueous flower extract (Hibiscus rosa-sinensis). Phytochemical screening of flower extract was done to identify bioactive components. Fabricated nanoparticles were characterized through Scanning Electron Microscopy (SEM), Transmission electron Microscopy (TEM), Energy Dispersive Spectroscopy (EDS), X-ray Diffraction (XRD), and Fourier-Transform Infrared Spectroscopy (FT-IR) to analyze their morphology, size, crystallinity, and elemental composition. Further, antimicrobial activity was evaluated against Escherichia coli and Rhizopus species.</div></div><div><h3>Results</h3><div>Phytochemical analysis of studied flower extract confirmed the presence of flavanone, coumarins, flavonoids, steroids, and anthocyanins in the flower extract. Characterization results demonstrated that the ZnO NPs were crystalline with an average size ranging from 7 to 14 nm, as revealed by XRD analysis. EDS confirmed the elemental composition of the nanoparticles. Antimicrobial assay observation indicates a good antibacterial and antifungal activity in fabricated ZnO NPs against E. coli and Rhizopus species, respectively.</div></div><div><h3>Discussion</h3><div>The present work revealed the successful green synthesis of ZnO NPs using H. rosa-sinensis flower extract and highlights the potential of its specific bioactive components documented in traditional Chinese medicine. The nanoparticles exhibited desirable properties with a good antimicrobial potential, suggesting their potential application in biomedical and environmental fields.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100673"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hibiscus rosa-sinensis flower extract-mediated fabrication of zinc oxide nanoparticles, characterization and its antimicrobial activity\",\"authors\":\"Komal Thakur , Avneet Kaur\",\"doi\":\"10.1016/j.prmcm.2025.100673\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div><em>Hibiscus rosa-sinensis</em> commonly known as Zhū Jǐn Huā' (朱槿花) which is widely beings used in Traditional Chinese Medicine (TCM) in the form of herbal preparations and decoctions for the ailment of inflammations, skin infections, and gynecological disorders. Zhū Jǐn Huā' (朱槿花) is well known for its good phytochemicals composition including anthocyanins, flavonoids and other bioactive components making it a promising choice for linking traditional Chinese medical knowledge with modern nanotechnology.</div></div><div><h3>Method</h3><div>ZnO NPs (Zinc oxide nanoparticles) were fabricated following simple chemical precipitation method using aqueous flower extract (Hibiscus rosa-sinensis). Phytochemical screening of flower extract was done to identify bioactive components. Fabricated nanoparticles were characterized through Scanning Electron Microscopy (SEM), Transmission electron Microscopy (TEM), Energy Dispersive Spectroscopy (EDS), X-ray Diffraction (XRD), and Fourier-Transform Infrared Spectroscopy (FT-IR) to analyze their morphology, size, crystallinity, and elemental composition. Further, antimicrobial activity was evaluated against Escherichia coli and Rhizopus species.</div></div><div><h3>Results</h3><div>Phytochemical analysis of studied flower extract confirmed the presence of flavanone, coumarins, flavonoids, steroids, and anthocyanins in the flower extract. Characterization results demonstrated that the ZnO NPs were crystalline with an average size ranging from 7 to 14 nm, as revealed by XRD analysis. EDS confirmed the elemental composition of the nanoparticles. Antimicrobial assay observation indicates a good antibacterial and antifungal activity in fabricated ZnO NPs against E. coli and Rhizopus species, respectively.</div></div><div><h3>Discussion</h3><div>The present work revealed the successful green synthesis of ZnO NPs using H. rosa-sinensis flower extract and highlights the potential of its specific bioactive components documented in traditional Chinese medicine. The nanoparticles exhibited desirable properties with a good antimicrobial potential, suggesting their potential application in biomedical and environmental fields.</div></div>\",\"PeriodicalId\":101013,\"journal\":{\"name\":\"Pharmacological Research - Modern Chinese Medicine\",\"volume\":\"16 \",\"pages\":\"Article 100673\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Modern Chinese Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667142525001009\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Modern Chinese Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667142525001009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

芙蓉（hibiscus rosa-sinensis），俗称zhu Jǐn花ā'（槿），广泛用于中药制剂和煎剂，用于炎症、皮肤感染和妇科疾病。花草Jǐn（槿）以其良好的植物化学成分而闻名，包括花青素、黄酮类化合物和其他生物活性成分，使其成为将传统中医知识与现代纳米技术联系起来的有希望的选择。方法以芙蓉花水提取物为原料，采用简单化学沉淀法制备氧化锌纳米粒子。对花提取物进行了植物化学筛选，以确定其生物活性成分。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、能谱（EDS）、x射线衍射（XRD）和傅里叶变换红外光谱（FT-IR）对制备的纳米颗粒进行表征，分析其形貌、尺寸、结晶度和元素组成。此外，还对大肠杆菌和根霉进行了抑菌活性评价。结果花提取物的植物化学分析证实，花提取物中含有黄酮、香豆素、黄酮类化合物、类固醇和花青素。表征结果表明，ZnO纳米粒子呈结晶状，XRD分析表明ZnO纳米粒子的平均尺寸为7 ~ 14 nm。能谱仪证实了纳米颗粒的元素组成。抑菌实验结果表明，制备的氧化锌NPs分别对大肠杆菌和根霉具有良好的抑菌和抑菌活性。本研究揭示了用紫红花提取物成功绿色合成氧化锌NPs的方法，并强调了其在传统中药中具有特殊生物活性成分的潜力。纳米颗粒表现出良好的抗菌性能，在生物医学和环境领域具有潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hibiscus rosa-sinensis flower extract-mediated fabrication of zinc oxide nanoparticles, characterization and its antimicrobial activity

查看原文本刊更多论文

Hibiscus rosa-sinensis flower extract-mediated fabrication of zinc oxide nanoparticles, characterization and its antimicrobial activity

Introduction

Hibiscus rosa-sinensis commonly known as Zhū Jǐn Huā' (朱槿花) which is widely beings used in Traditional Chinese Medicine (TCM) in the form of herbal preparations and decoctions for the ailment of inflammations, skin infections, and gynecological disorders. Zhū Jǐn Huā' (朱槿花) is well known for its good phytochemicals composition including anthocyanins, flavonoids and other bioactive components making it a promising choice for linking traditional Chinese medical knowledge with modern nanotechnology.

Method

ZnO NPs (Zinc oxide nanoparticles) were fabricated following simple chemical precipitation method using aqueous flower extract (Hibiscus rosa-sinensis). Phytochemical screening of flower extract was done to identify bioactive components. Fabricated nanoparticles were characterized through Scanning Electron Microscopy (SEM), Transmission electron Microscopy (TEM), Energy Dispersive Spectroscopy (EDS), X-ray Diffraction (XRD), and Fourier-Transform Infrared Spectroscopy (FT-IR) to analyze their morphology, size, crystallinity, and elemental composition. Further, antimicrobial activity was evaluated against Escherichia coli and Rhizopus species.

Results

Phytochemical analysis of studied flower extract confirmed the presence of flavanone, coumarins, flavonoids, steroids, and anthocyanins in the flower extract. Characterization results demonstrated that the ZnO NPs were crystalline with an average size ranging from 7 to 14 nm, as revealed by XRD analysis. EDS confirmed the elemental composition of the nanoparticles. Antimicrobial assay observation indicates a good antibacterial and antifungal activity in fabricated ZnO NPs against E. coli and Rhizopus species, respectively.

Discussion

The present work revealed the successful green synthesis of ZnO NPs using H. rosa-sinensis flower extract and highlights the potential of its specific bioactive components documented in traditional Chinese medicine. The nanoparticles exhibited desirable properties with a good antimicrobial potential, suggesting their potential application in biomedical and environmental fields.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pharmacological Research - Modern Chinese Medicine

CiteScore

1.60

自引率

0.00%

发文量