组织转谷氨酰胺酶免疫球蛋白A升高：乳糜泻还是多型浆细胞病？

JPGN reports Pub Date : 2025-06-02 eCollection Date: 2025-08-01 DOI:10.1002/jpr3.70037

Andrew Turunen, Aisha Ahmed, Philip Thrush, Paula North, Ankur Chugh

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摘要

我们报告一例青春期女孩心脏移植后高γ球蛋白血症和推测乳糜泻（CD），谁有持续升高的抗组织转谷氨酰胺酶免疫球蛋白a，尽管无麸质饮食。排除难治性乳糜泻和克罗恩病。同时消除乳制品导致乳糜泻滴度正常化，但没有组织学改善。最终，她被诊断为多型浆细胞病，疑似免疫失调。

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Elevated tissue transglutaminase immunoglobulin A: Celiac disease or polytypic plasmacytosis?

We report a case of an adolescent girl post cardiac transplant with hypergammaglobulinemia and presumed celiac disease (CD), who had a persistently elevated anti-tissue transglutaminase immunoglobulin A despite a gluten free diet. Refractory CD and Crohn's disease were excluded. Concomitant dairy elimination led to normalization of celiac titers but no histological improvement. Ultimately, she was diagnosed with polytypic plasmacytosis from suspected immune dysregulation.

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JPGN reports

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