北京地区婴幼儿接种卡介苗后播散性卡介苗感染3例分析。

IF 3.5 4区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-08-14 DOI:10.1080/21645515.2025.2537482

Li Li, Jingyi Xu, Jianlin Cai, Mei Wang, Fang Wang, Liqing Yang, Yunhua Bai, Bin Jia, Shuping Li

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引用次数: 0

摘要

我们报告并分析了北京朝阳区在2022 - 2024年间接种卡介苗后发生的3例婴儿播散性卡介苗感染病例，这是我们在临床应用中仅有的3例监测病例。所有患者均为原发性免疫缺陷病（PID）。2例存在JAK3和TNFRSF13B基因缺陷；1例在DOCK11的CR2、IFNAR2、TLR2和外显子13中存在多个基因缺陷。播散性卡介苗感染是卡介苗接种后罕见的不良反应。它几乎只发生在免疫缺陷的婴儿或儿童身上。虽然很少发生，但由于其后果严重，临床上应予以重视。

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Analysis of three cases of disseminated BCG infection in infants after BCG vaccination in Beijing, China.

We report and analyze three cases of disseminated BCG infection in infants after BCG vaccination that occurred between 2022 and 2024 in Chaoyang District, Beijing, which were the only three monitored during the clinical application we conducted. All the patients had primary immunodeficiency disease (PID). Two cases had defects in the JAK3 and TNFRSF13B genes; one case had multiple gene defects in CR2, IFNAR2, TLR2, and exon 13 of DOCK11. Disseminated BCG infection is a rare adverse reaction after BCG vaccination. It occurs almost exclusively in immunodeficient infants or children. Although it rarely occurs, it is necessary to pay more attention to clinical practice because of its serious consequences.

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来源期刊

Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY

CiteScore

7.90

自引率

8.30%

发文量

489

审稿时长

3-6 weeks

期刊介绍： (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.