{"title":"在人口调查中使用毛发皮质醇测量对慢性疼痛的恢复力。","authors":"Tarani Chandola, Stephanie Cahill, Wanying Ling, Meena Kumari","doi":"10.1017/S0033291725101049","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic pain activates the HPA axis stress response resulting in the release of cortisol, although empirical associations are often contradictory. Quantile regression models of hair cortisol may help us measure HPA-axis dysregulation more accurately and establish more robust associations with chronic pain. We also examined whether people with chronic pain characterised by HPA-axis dysregulation are at risk of future mental ill-health.</p><p><strong>Methods: </strong>This study examined data from the English Longitudinal Study of Ageing (ELSA, <i>n</i> = 4,560) and the UK Household Longitudinal Survey-Innovation Panel (UKHLS-IP, <i>n</i> = 473) to assess whether quantile regression methods enable us to assess more robust associations between hair cortisol and chronic pain, and whether older adults with chronic pain characterised by HPA-axis dysregulation are at risk of future mental ill-health.</p><p><strong>Results: </strong>In ELSA, chronic pain was associated with a 15% (CI: 6%-23%) increase in cortisol at the 10th percentile of the hair cortisol distribution among older adults and a 19% (CI: 2%-37%) increase at the 80th percentile, but no association was found at the 30th or 40th percentiles. Having a low cortisol response to chronic pain protected against the recurrence of depression. These patterns of association were replicated in the UKHLS-IP sample.</p><p><strong>Conclusions: </strong>The associations demonstrated across two longitudinal population surveys from the UK indicate that quantile regression analysis of hair cortisol may be useful in identifying individuals resilient to chronic pain. Hair cortisol is a promising biomarker that can be measured in population studies to quantify the stress response and resilience to future mental ill-health.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e201"},"PeriodicalIF":5.5000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404322/pdf/","citationCount":"0","resultStr":"{\"title\":\"Measuring resilience to chronic pain in population surveys using hair cortisol.\",\"authors\":\"Tarani Chandola, Stephanie Cahill, Wanying Ling, Meena Kumari\",\"doi\":\"10.1017/S0033291725101049\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic pain activates the HPA axis stress response resulting in the release of cortisol, although empirical associations are often contradictory. Quantile regression models of hair cortisol may help us measure HPA-axis dysregulation more accurately and establish more robust associations with chronic pain. We also examined whether people with chronic pain characterised by HPA-axis dysregulation are at risk of future mental ill-health.</p><p><strong>Methods: </strong>This study examined data from the English Longitudinal Study of Ageing (ELSA, <i>n</i> = 4,560) and the UK Household Longitudinal Survey-Innovation Panel (UKHLS-IP, <i>n</i> = 473) to assess whether quantile regression methods enable us to assess more robust associations between hair cortisol and chronic pain, and whether older adults with chronic pain characterised by HPA-axis dysregulation are at risk of future mental ill-health.</p><p><strong>Results: </strong>In ELSA, chronic pain was associated with a 15% (CI: 6%-23%) increase in cortisol at the 10th percentile of the hair cortisol distribution among older adults and a 19% (CI: 2%-37%) increase at the 80th percentile, but no association was found at the 30th or 40th percentiles. Having a low cortisol response to chronic pain protected against the recurrence of depression. These patterns of association were replicated in the UKHLS-IP sample.</p><p><strong>Conclusions: </strong>The associations demonstrated across two longitudinal population surveys from the UK indicate that quantile regression analysis of hair cortisol may be useful in identifying individuals resilient to chronic pain. Hair cortisol is a promising biomarker that can be measured in population studies to quantify the stress response and resilience to future mental ill-health.</p>\",\"PeriodicalId\":20891,\"journal\":{\"name\":\"Psychological Medicine\",\"volume\":\"55 \",\"pages\":\"e201\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404322/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychological Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/S0033291725101049\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychological Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0033291725101049","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
摘要
背景:慢性疼痛激活下丘脑轴应激反应,导致皮质醇的释放,尽管经验关联往往是矛盾的。毛发皮质醇的分位数回归模型可以帮助我们更准确地测量hpa轴失调,并建立与慢性疼痛的更强大的联系。我们还研究了以hpa轴失调为特征的慢性疼痛患者是否有未来精神疾病的风险。方法:本研究检查了来自英国老龄化纵向研究(ELSA, n = 4560)和英国家庭纵向调查-创新小组(UKHLS-IP, n = 473)的数据,以评估分位数回归方法是否使我们能够评估头发皮质醇与慢性疼痛之间更强的关联,以及以hpa轴失调为特征的慢性疼痛老年人是否有未来精神疾病的风险。结果:在ELSA中,慢性疼痛与老年人头发皮质醇分布的第10百分位数的皮质醇增加15% (CI: 6%-23%)和第80百分位数的皮质醇增加19% (CI: 2%-37%)相关,但在第30或第40百分位数没有发现关联。对慢性疼痛的低皮质醇反应可以防止抑郁症的复发。这些关联模式在UKHLS-IP样本中被复制。结论:来自英国的两项纵向人口调查表明,头发皮质醇的分位数回归分析可能有助于识别对慢性疼痛有弹性的个体。毛发皮质醇是一种很有前途的生物标志物,可以在人口研究中测量,量化压力反应和对未来精神疾病的恢复能力。
Measuring resilience to chronic pain in population surveys using hair cortisol.
Background: Chronic pain activates the HPA axis stress response resulting in the release of cortisol, although empirical associations are often contradictory. Quantile regression models of hair cortisol may help us measure HPA-axis dysregulation more accurately and establish more robust associations with chronic pain. We also examined whether people with chronic pain characterised by HPA-axis dysregulation are at risk of future mental ill-health.
Methods: This study examined data from the English Longitudinal Study of Ageing (ELSA, n = 4,560) and the UK Household Longitudinal Survey-Innovation Panel (UKHLS-IP, n = 473) to assess whether quantile regression methods enable us to assess more robust associations between hair cortisol and chronic pain, and whether older adults with chronic pain characterised by HPA-axis dysregulation are at risk of future mental ill-health.
Results: In ELSA, chronic pain was associated with a 15% (CI: 6%-23%) increase in cortisol at the 10th percentile of the hair cortisol distribution among older adults and a 19% (CI: 2%-37%) increase at the 80th percentile, but no association was found at the 30th or 40th percentiles. Having a low cortisol response to chronic pain protected against the recurrence of depression. These patterns of association were replicated in the UKHLS-IP sample.
Conclusions: The associations demonstrated across two longitudinal population surveys from the UK indicate that quantile regression analysis of hair cortisol may be useful in identifying individuals resilient to chronic pain. Hair cortisol is a promising biomarker that can be measured in population studies to quantify the stress response and resilience to future mental ill-health.
期刊介绍:
Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.