Alberto Bellelli, Valerio D'Andrea, Matteo Pileri, Bruno Beomonte Zobel
{"title":"ct引导下氧-臭氧（O2-O3）治疗腰痛的疗效和安全性：一项回顾性单中心研究","authors":"Alberto Bellelli, Valerio D'Andrea, Matteo Pileri, Bruno Beomonte Zobel","doi":"10.1007/s11547-025-02071-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Oxygen-ozone (O<sub>2</sub>-O<sub>3</sub>) therapy is increasingly recognized as a minimally invasive option for managing low back pain (LBP). This study aims to assess the efficacy and safety of CT-guided O<sub>2</sub>-O<sub>3</sub> injections, both as a standalone therapy and in combination with other medications, across a diverse cohort of patients with LBP.</p><p><strong>Materials and methods: </strong>We conducted a single-center retrospective observational study of patients with LBP who underwent CT-guided O<sub>2</sub>-O<sub>3</sub> intradiscal and/or facet joint injections between January 2016 and March 2017. Patients were categorized into three groups: Group A (facet joint osteoarthritis), Group B (single-level disc herniation with unilateral sciatica), and Group C (double-level disc herniation with bilateral or unilateral sciatica). Pain intensity was assessed using the Visual Analog Scale (VAS) at baseline and three weeks after the final injection. Statistical analysis included paired t-tests for pre- and post-treatment comparisons and one-way ANOVA with Tukey's HSD for group comparisons.</p><p><strong>Results: </strong>A total of 123 patients were included. The mean baseline VAS score for the entire cohort was 7.5 ± 1.2, which significantly decreased to 3.5 ± 1.5 following treatment (T = 43.74, p < 0.001). In Group A, the mean VAS decreased from 7.2 ± 1.3 to 3.8 ± 1.4; in Group B, from 7.8 ± 1.0 to 3.2 ± 1.3; and in Group C, from 8.0 ± 0.9 to 3.0 ± 1.2. ANOVA revealed significant differences in post-treatment VAS scores among groups (F = 27.36, p < 0.001). Tukey's HSD indicated significant differences between Groups A and B (p < 0.001) and A and C (p < 0.001), with no significant difference between Groups B and C (p = 0.247). Overall, 21.95% of patients experienced significant improvement (VAS reduction > 4 points), 57.72% had moderate improvement (VAS reduction 2-4 points), and 18.7% showed minimal improvement (VAS reduction ≤ 1 point). No complications were reported during or after the procedures.</p><p><strong>Conclusion: </strong>The findings strongly support the efficacy and safety of O<sub>2</sub>-O<sub>3</sub> therapy for the treatment of LBP, offering significant short-term pain relief across diverse patient subgroups. Further controlled studies are warranted to confirm long-term efficacy and optimize treatment protocols.</p>","PeriodicalId":20817,"journal":{"name":"Radiologia Medica","volume":" ","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy and safety of CT-guided oxygen-ozone (O<sub>2</sub>-O<sub>3</sub>) therapy for low back pain: a retrospective single-center study.\",\"authors\":\"Alberto Bellelli, Valerio D'Andrea, Matteo Pileri, Bruno Beomonte Zobel\",\"doi\":\"10.1007/s11547-025-02071-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Oxygen-ozone (O<sub>2</sub>-O<sub>3</sub>) therapy is increasingly recognized as a minimally invasive option for managing low back pain (LBP). This study aims to assess the efficacy and safety of CT-guided O<sub>2</sub>-O<sub>3</sub> injections, both as a standalone therapy and in combination with other medications, across a diverse cohort of patients with LBP.</p><p><strong>Materials and methods: </strong>We conducted a single-center retrospective observational study of patients with LBP who underwent CT-guided O<sub>2</sub>-O<sub>3</sub> intradiscal and/or facet joint injections between January 2016 and March 2017. Patients were categorized into three groups: Group A (facet joint osteoarthritis), Group B (single-level disc herniation with unilateral sciatica), and Group C (double-level disc herniation with bilateral or unilateral sciatica). Pain intensity was assessed using the Visual Analog Scale (VAS) at baseline and three weeks after the final injection. Statistical analysis included paired t-tests for pre- and post-treatment comparisons and one-way ANOVA with Tukey's HSD for group comparisons.</p><p><strong>Results: </strong>A total of 123 patients were included. The mean baseline VAS score for the entire cohort was 7.5 ± 1.2, which significantly decreased to 3.5 ± 1.5 following treatment (T = 43.74, p < 0.001). In Group A, the mean VAS decreased from 7.2 ± 1.3 to 3.8 ± 1.4; in Group B, from 7.8 ± 1.0 to 3.2 ± 1.3; and in Group C, from 8.0 ± 0.9 to 3.0 ± 1.2. ANOVA revealed significant differences in post-treatment VAS scores among groups (F = 27.36, p < 0.001). Tukey's HSD indicated significant differences between Groups A and B (p < 0.001) and A and C (p < 0.001), with no significant difference between Groups B and C (p = 0.247). 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引用次数: 0
摘要
目的：氧-臭氧（O2-O3）治疗越来越被认为是治疗腰痛（LBP）的一种微创选择。本研究旨在评估ct引导下的O2-O3注射的有效性和安全性，无论是作为单独治疗还是与其他药物联合治疗，在不同的LBP患者队列中。材料和方法：我们对2016年1月至2017年3月期间接受ct引导下椎间盘内和/或小关节面注射的腰痛患者进行了一项单中心回顾性观察研究。患者分为三组：A组（小关节骨性关节炎），B组（单侧坐骨神经痛单节段椎间盘突出），C组（双节段椎间盘突出伴双侧或单侧坐骨神经痛）。在基线和末次注射后3周采用视觉模拟评分（VAS）评估疼痛强度。统计分析包括治疗前后比较的配对t检验和组比较的单因素方差分析。结果：共纳入123例患者。整个队列的平均基线VAS评分为7.5±1.2分，治疗后显著降低至3.5±1.5分（T = 43.74, p = 4分），57.72%的患者有中度改善（VAS降低2-4分），18.7%的患者有轻微改善（VAS降低≤1分）。术中及术后无并发症。结论：研究结果有力地支持了O2-O3治疗腰痛的有效性和安全性，在不同的患者亚组中提供了显着的短期疼痛缓解。需要进一步的对照研究来确认长期疗效并优化治疗方案。
Efficacy and safety of CT-guided oxygen-ozone (O2-O3) therapy for low back pain: a retrospective single-center study.
Purpose: Oxygen-ozone (O2-O3) therapy is increasingly recognized as a minimally invasive option for managing low back pain (LBP). This study aims to assess the efficacy and safety of CT-guided O2-O3 injections, both as a standalone therapy and in combination with other medications, across a diverse cohort of patients with LBP.
Materials and methods: We conducted a single-center retrospective observational study of patients with LBP who underwent CT-guided O2-O3 intradiscal and/or facet joint injections between January 2016 and March 2017. Patients were categorized into three groups: Group A (facet joint osteoarthritis), Group B (single-level disc herniation with unilateral sciatica), and Group C (double-level disc herniation with bilateral or unilateral sciatica). Pain intensity was assessed using the Visual Analog Scale (VAS) at baseline and three weeks after the final injection. Statistical analysis included paired t-tests for pre- and post-treatment comparisons and one-way ANOVA with Tukey's HSD for group comparisons.
Results: A total of 123 patients were included. The mean baseline VAS score for the entire cohort was 7.5 ± 1.2, which significantly decreased to 3.5 ± 1.5 following treatment (T = 43.74, p < 0.001). In Group A, the mean VAS decreased from 7.2 ± 1.3 to 3.8 ± 1.4; in Group B, from 7.8 ± 1.0 to 3.2 ± 1.3; and in Group C, from 8.0 ± 0.9 to 3.0 ± 1.2. ANOVA revealed significant differences in post-treatment VAS scores among groups (F = 27.36, p < 0.001). Tukey's HSD indicated significant differences between Groups A and B (p < 0.001) and A and C (p < 0.001), with no significant difference between Groups B and C (p = 0.247). Overall, 21.95% of patients experienced significant improvement (VAS reduction > 4 points), 57.72% had moderate improvement (VAS reduction 2-4 points), and 18.7% showed minimal improvement (VAS reduction ≤ 1 point). No complications were reported during or after the procedures.
Conclusion: The findings strongly support the efficacy and safety of O2-O3 therapy for the treatment of LBP, offering significant short-term pain relief across diverse patient subgroups. Further controlled studies are warranted to confirm long-term efficacy and optimize treatment protocols.
期刊介绍：
Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.
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