长链非编码、微rna和环状rna在卵巢癌转移中的作用:途径和治疗方法。

IF 2.5 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Reproductive Sciences Pub Date : 2025-09-01 Epub Date: 2025-08-15 DOI:10.1007/s43032-025-01948-x
Meeral Gosia, Gaurav Doshi, Siddhi Parab, Angel Godad
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引用次数: 0

摘要

妇科癌症是妇女死亡的一个主要原因,最著名的卵巢癌死亡率很高。鉴于大多数卵巢癌死亡是由转移性肿瘤扩散到附近组织引起的,一些生物过程,包括血管生成和转移,在这些疾病的发生和发展过程中起作用。最近的研究表明,许多非编码rna (ncRNAs)通过改变特定的细胞途径参与卵巢癌的侵袭和转移。三种形式的非编码rna,即长链非编码rna,微rna和环状rna是本综述的主题。miRNA被用作潜在的生物标志物,如miR-375,它是一种血清外泌体,也用于治疗。lncRNA与隔离和调节肿瘤进展的miRNA(如XIST miR-149-3p)相结合。circRNA靶向蛋白质并调节基因表达。本文综述了非编码rna在促进恶性肿瘤侵袭和转移的多种途径和分子交换中的确切功能。为了提高OC患者的生存率,ncrna靶向治疗的新方法正在被使用,包括靶向lncrna和circrna以及使用外泌体调节肿瘤微环境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long Non-Coding, Micro, and Circular RNAs in Ovarian Cancer Metastasis: Pathways and Treatment Approaches.

Gynaecologic cancer is a major cause of death for women and the most well-known ovarian cancer (OC) has a high mortality rate. Given that the majority of ovarian cancer deaths are caused by metastatic tumors that have spread to nearby tissues, several biological processes, including angiogenesis and metastasis, have a role in the onset and course of these diseases. Numerous non-coding RNAs (ncRNAs) have been shown in recent studies to contribute to the invasion and metastasis of ovarian cancer by altering particular cellular pathways. Three forms of ncRNAs which are long non-coding RNAs, micro RNAs, and circular RNAs are the subjects of this review. miRNA is used as a potential biomarker such as miR-375 which is a serum exosome and also in therapeutics. lncRNA sponges with miRNA which sequesters and regulates tumor progression such as XIST miR-149-3p. circRNA targets proteins and regulates gene expression. This review provides an overview of the precise function of non-coding RNAs in the many pathways and molecular exchanges that contribute to the invasion and metastasis of malignancies. To increase the survival rate of OC patients, new approaches to ncRNA-targeted therapy are being utilised, including targeting lncRNAs and circRNAs and modulating the tumor microenvironment using exosomes.

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来源期刊
Reproductive Sciences
Reproductive Sciences 医学-妇产科学
CiteScore
5.50
自引率
3.40%
发文量
322
审稿时长
4-8 weeks
期刊介绍: Reproductive Sciences (RS) is a peer-reviewed, monthly journal publishing original research and reviews in obstetrics and gynecology. RS is multi-disciplinary and includes research in basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.
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