儿童狼疮的疾病活动轨迹及其与社会经济因素和患者报告的疼痛的关联。

IF 3.5 2区 医学 Q1 RHEUMATOLOGY
Siobhan Case, C Larry Hill, Peter Shrader, Anne Dennos, Thomas Phillips, Laura Eve Schanberg, Emily von Scheven, Kamil Barbour, Andrea M Knight, Aimee Hersh, MaryBeth Son
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引用次数: 0

摘要

目的:使用儿童关节炎和风湿病研究联盟注册的儿童SLE (pSLE)参与者的数据,我们旨在:(1)描述2年的疾病活动轨迹,由SLE疾病活动指数2000 (SLEDAI 2K)测量;(2)确定与每个轨迹相关的特征;(3)评估狼疮低疾病活动状态(LLDAS)和相关基线特征的实现情况。方法:参与者在基线访问的12个月内被诊断为pSLE。基线社会人口学、临床和治疗特征包括在潜在轨迹分析中。采用多项广义逻辑回归模型分析患者特征与轨迹组和LLDAS之间的关系。结果:共筛选1002例患者;SLEDAI 2K纳入553例,LLDAS纳入269例。SLEDAI 2K轨迹包括(T1)低且稳定,(T2)高且递减,(T3)中且稳定。在多项广义逻辑回归中,基线SLEDAI 2K评分和保险类型与轨迹显著相关。51%(136/269)的患者在24个月内至少获得一次LLDAS,而首次评估时为17%(47/269)。通过较低的疼痛干扰评分预测两个时间点的LLDAS实现情况;超过24个月的LLDAS水平也与基线美国风湿病学会分类标准、基线美罗华单抗使用和最高完成的父母/监护人教育水平相关。结论:pSLE队列中的疾病活动轨迹可以通过基线SLEDAI 2K和保险来预测。在2年的研究期间,只有一半的患者达到了LLDAS,这是通过包括疼痛干扰在内的基线特征来预测的。疾病活动性与社会经济因素和疼痛之间的关系值得进一步研究,以确定减少pSLE疾病活动性的可改变因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Disease activity trajectories in paediatric lupus and associations with socioeconomic factors and patient-reported pain.

Disease activity trajectories in paediatric lupus and associations with socioeconomic factors and patient-reported pain.

Disease activity trajectories in paediatric lupus and associations with socioeconomic factors and patient-reported pain.

Objective: Using data from participants with paediatric SLE (pSLE) in the Childhood Arthritis and Rheumatology Research Alliance Registry, we aimed to: (1) describe 2-year disease activity trajectories, measured by the SLE Disease Activity Index 2000 (SLEDAI 2K); (2) identify characteristics associated with each trajectory and (3) assess achievement of lupus low disease activity state (LLDAS) and associated baseline characteristics.

Methods: Participants were diagnosed with pSLE within 12 months of baseline visit. Baseline sociodemographic, clinical and treatment characteristics were included in latent trajectory analyses. Associations between patient characteristics with trajectory groups and LLDAS were analysed with multinomial generalised logistic regression modelling.

Results: 1002 patients were screened; 553 were included for SLEDAI 2K and 269 for LLDAS analyses. SLEDAI 2K trajectories included (T1) low and stable, (T2) high and decreasing, (T3) intermediate and stable. In multinomial generalised logistic regression, baseline SLEDAI 2K score and insurance type were significantly associated with trajectories. 51% (136/269) of patients achieved LLDAS at least once in 24 months as compared with 17% (47/269) at first assessment. LLDAS attainment at both time points was predicted by lower pain interference scores; LLDAS attainment over 24 months was also associated with baseline American College of Rheumatology classification criteria, rituximab use at baseline and highest completed level of parent/guardian education.

Conclusions: Disease activity trajectories in a pSLE cohort were predicted by baseline SLEDAI 2K and insurance. Only half of the patients achieved LLDAS during the 2-year study period, which was predicted by baseline characteristics including pain interference. The relationship between disease activity and socioeconomic factors and pain warrants further investigation to identify modifiable factors to reduce pSLE disease activity.

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来源期刊
Lupus Science & Medicine
Lupus Science & Medicine RHEUMATOLOGY-
CiteScore
5.30
自引率
7.70%
发文量
88
审稿时长
15 weeks
期刊介绍: Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.
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