合成功能化的单、双、三（螺磷酰）胺和氨基酸

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-08-16 DOI:10.1007/s11172-025-4698-z

Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin

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引用次数: 0

摘要

以1,4,6,9-四氧基-5 - λ5-磷酸[4.4]壬烷型氢螺磷烷为基础，利用单、双、三胺甲基化试剂，方便地合成了含单、二、三（螺磷酰甲基）胺和类似氨基酸的功能化pch2n。N，N-二取代氨基甲基膦酸二乙酯与乙二醇的酯交换伴随着氧化还原过程，并提供氨基甲基旋磷烷。目标化合物作为生物活性物质、多齿螯合配体以及有前途的含磷聚合物的合成单体具有重要意义。

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Synthesis of functionalized mono-, bis-, and tris(spirophosphoranyl) amines and amino acids

Convenient syntheses of functionalized PCH₂N-containing mono-, bis-, and tris-(spirophosphoranylmethyl)amines and analogous amino acids based on hydrospirophosphoranes of the 1,4,6,9-tetraoxa-5λ⁵-phosphaspiro[4.4]nonane type using mono-, bis-, and tris-aminomethylating agents have been developed. Transesterification of diethyl esters of N,N-disubstituted aminomethylphosphonous acids with ethylene glycol is accompanied by a redox process and furnishes aminomethylspirophosphoranes. The target compounds are of interest as biologically active substances, polydentate chelating ligands, and also as promising monomers for the synthesis of phosphorus-containing polymers.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.