{"title":"一种同步电位/电流非酶多巴胺传感器的传感特性","authors":"Jung-Chuan Chou;Wei-Shun Chen;Po-Hui Yang;Yu-Hsun Nien;Chih-Hsien Lai;Po-Yu Kuo;Jyun-Ming Huang;Yu-Wei Chen","doi":"10.1109/JSEN.2025.3588843","DOIUrl":null,"url":null,"abstract":"In this study, a flexible dopamine (DA) sensor based on an electroless nickel immersion gold (ENIG) substrate is proposed. A Cu2O thin film provides high electrical conductivity and chemical stability, and WO3 nanoparticles (WO3 NPs) provide excellent catalytic activity and selectivity for DA detection. The Cu2O/WO3NPs heterostructure can be operated in both potentiometric and amperometric modes, markedly increasing its utility. Across 0.01–100-<inline-formula> <tex-math>$\\mu $ </tex-math></inline-formula>M DA, the sensor delivers average sensitivities of 33.0 mV dec<inline-formula> <tex-math>${}^{-{1}}$ </tex-math></inline-formula> (potentiometric) and <inline-formula> <tex-math>$220.7~\\mu $ </tex-math></inline-formula>A <inline-formula> <tex-math>$\\mu $ </tex-math></inline-formula>M<inline-formula> <tex-math>${}^{-{1}}$ </tex-math></inline-formula>cm<inline-formula> <tex-math>${}^{-{2}}$ </tex-math></inline-formula> (amperometric). The detection limits, selectivity, and reproducibility are all within acceptable standards under either mode of operation. The WO3 NPs/Cu2O/ENIG sensor exhibits excellent discrimination against common interferents and has consistent analytical performance. This form of DA sensor has tremendous potential as a versatile neurotransmitter monitoring solution, in either laboratory or point-of-care settings.","PeriodicalId":447,"journal":{"name":"IEEE Sensors Journal","volume":"25 16","pages":"30379-30386"},"PeriodicalIF":4.3000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sensing Characteristics of a Simultaneous Potentiometric/Amperometric Nonenzymatic Dopamine Sensor\",\"authors\":\"Jung-Chuan Chou;Wei-Shun Chen;Po-Hui Yang;Yu-Hsun Nien;Chih-Hsien Lai;Po-Yu Kuo;Jyun-Ming Huang;Yu-Wei Chen\",\"doi\":\"10.1109/JSEN.2025.3588843\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, a flexible dopamine (DA) sensor based on an electroless nickel immersion gold (ENIG) substrate is proposed. A Cu2O thin film provides high electrical conductivity and chemical stability, and WO3 nanoparticles (WO3 NPs) provide excellent catalytic activity and selectivity for DA detection. The Cu2O/WO3NPs heterostructure can be operated in both potentiometric and amperometric modes, markedly increasing its utility. Across 0.01–100-<inline-formula> <tex-math>$\\\\mu $ </tex-math></inline-formula>M DA, the sensor delivers average sensitivities of 33.0 mV dec<inline-formula> <tex-math>${}^{-{1}}$ </tex-math></inline-formula> (potentiometric) and <inline-formula> <tex-math>$220.7~\\\\mu $ </tex-math></inline-formula>A <inline-formula> <tex-math>$\\\\mu $ </tex-math></inline-formula>M<inline-formula> <tex-math>${}^{-{1}}$ </tex-math></inline-formula>cm<inline-formula> <tex-math>${}^{-{2}}$ </tex-math></inline-formula> (amperometric). The detection limits, selectivity, and reproducibility are all within acceptable standards under either mode of operation. The WO3 NPs/Cu2O/ENIG sensor exhibits excellent discrimination against common interferents and has consistent analytical performance. This form of DA sensor has tremendous potential as a versatile neurotransmitter monitoring solution, in either laboratory or point-of-care settings.\",\"PeriodicalId\":447,\"journal\":{\"name\":\"IEEE Sensors Journal\",\"volume\":\"25 16\",\"pages\":\"30379-30386\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE Sensors Journal\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://ieeexplore.ieee.org/document/11087523/\",\"RegionNum\":2,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Sensors Journal","FirstCategoryId":"103","ListUrlMain":"https://ieeexplore.ieee.org/document/11087523/","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
摘要
在这项研究中,提出了一种基于化学镍浸金(ENIG)衬底的柔性多巴胺(DA)传感器。Cu2O薄膜具有高导电性和化学稳定性,而WO3纳米颗粒(WO3 NPs)对DA检测具有优异的催化活性和选择性。Cu2O/WO3NPs异质结构可以在电位模式和安培模式下工作,显著提高了其实用性。在0.01-100 - $\mu $ M DA范围内,传感器的平均灵敏度为33.0 mV dec ${}^{-{1}}$(电位计)和$220.7~\mu $ A $\mu $ M ${}^{-{1}}$ cm ${}^{-{2}}$(安培计)。在任何一种操作模式下,检测限、选择性和重现性都在可接受的标准范围内。wo3nps /Cu2O/ENIG传感器对常见干扰具有良好的分辨能力,分析性能一致。这种形式的DA传感器具有巨大的潜力,作为一个多功能的神经递质监测解决方案,在实验室或护理点设置。
Sensing Characteristics of a Simultaneous Potentiometric/Amperometric Nonenzymatic Dopamine Sensor
In this study, a flexible dopamine (DA) sensor based on an electroless nickel immersion gold (ENIG) substrate is proposed. A Cu2O thin film provides high electrical conductivity and chemical stability, and WO3 nanoparticles (WO3 NPs) provide excellent catalytic activity and selectivity for DA detection. The Cu2O/WO3NPs heterostructure can be operated in both potentiometric and amperometric modes, markedly increasing its utility. Across 0.01–100-$\mu $ M DA, the sensor delivers average sensitivities of 33.0 mV dec${}^{-{1}}$ (potentiometric) and $220.7~\mu $ A $\mu $ M${}^{-{1}}$ cm${}^{-{2}}$ (amperometric). The detection limits, selectivity, and reproducibility are all within acceptable standards under either mode of operation. The WO3 NPs/Cu2O/ENIG sensor exhibits excellent discrimination against common interferents and has consistent analytical performance. This form of DA sensor has tremendous potential as a versatile neurotransmitter monitoring solution, in either laboratory or point-of-care settings.
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