忠实遗传：裂变酵母亲本组蛋白循环和表观遗传记忆

Cell insight Pub Date : 2025-08-08 DOI:10.1016/j.cellin.2025.100275

Yimeng Fang , Takenori Toda , Songtao Jia

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引用次数: 0

摘要

DNA复制过程中染色质状态的准确传递是表观遗传的核心。最近的进展已经阐明了携带关键翻译后修饰的亲本组蛋白被回收并重新分配到子链的机制。这篇综述综合了在复制过程中介导组蛋白循环的分子机制的新见解。它强调了组蛋白伴侣和复制因子之间的相互作用，并研究了这些途径中的扰动如何影响异染色质遗传。裂变酵母为最近的研究提供了一个强大的模型，揭示了在真核生物中保守的新原理。

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Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast

Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled and redistributed to daughter strands. This review synthesizes emerging insights into the molecular machinery that mediates histone recycling during replication. It highlights the interplay between histone chaperones and replication factors and examines how perturbations in these pathways influence heterochromatin inheritance. The fission yeast serves as a powerful model for recent investigations, revealing new principles that are conserved across eukaryotes.

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来源期刊

Cell insight Neuroscience (General), Biochemistry, Genetics and Molecular Biology (General), Cancer Research, Cell Biology

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

35 days