年轻男性和年轻女性大脑区域同质性差异：静息状态功能磁共振成像研究

IF 2.9 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2025-08-12 DOI:10.1016/j.ibneur.2025.08.006

Xiaoci Li , Lingling Sun , Ziyu Zeng , Shihong Yan , Abao Rui , Jian Cai , Qingyu Wang , Jian Mei , Yun Yu , Yue Yu

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引用次数: 0

摘要

目的通过计算静息状态功能磁共振成像（rs-fMRI）的区域均匀性（ReHo）值，探讨健康青年大脑的性别差异。从而为神经退行性疾病的风险分层提供候选成像生物标志物，并为其早期筛查和靶向干预提供基础。方法对42例健康青年（男21例，女21例）进行静息态功能磁共振成像（fMRI）检查。我们采用区域均匀性（ReHo）的统计方法对男性和女性的大脑进行比较。结果与男性组相比，女性组右侧边缘上回的活动强度较高，而左侧背外侧前额叶皮层、右侧额叶视野、右侧运动前皮层和右侧颞上回的活动强度显著低于男性组。结论男性在工作记忆、有意识决策行为、视觉运动技能、身体反应速度、节奏感知和语言感知方面具有较大优势，而女性在情景记忆和视觉想象方面具有较大优势。男性左侧DLPFC的高ReHo是男性AD高危人群的筛查标志物。女性右上边缘回的高ReHo是PTSD或抑郁症的早期预警生物标志物。

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Regional homogeneity differences between the brains of young men and young women: A resting-state functional magnetic resonance imaging study

Objective

The aim of the study was to investigate gender differences in the brains of young healthy adults, by calculating the regional homogeneity (ReHo) values of resting-state functional magnetic resonance imaging (rs-fMRI). Thereby providing candidate imaging biomarkers for risk stratification of neurodegenerative diseases and offering a basis for their early screening and targeted intervention.

Methods

Forty-two (42) healthy young adults (21males and 21females) were examined using resting-state fMRI. We employed the statistical method of regional homogeneity (ReHo) to compare the brains of males and females.

Results

The female group exhibited higher activity intensity in the right supramarginal gyrus, but significantly lower activity intensity in the left dorsolateral prefrontal cortex, the right frontal eye field, the right premotor cortex and the right superior temporal gyrus compared to the male group.

Conclusion

Males have greater advantages in working memory, conscious decision-making behavior, visual-motor skills, physical reaction speed, rhythmic perception and language perception, while females show better episodic memory and visual imagination. High ReHo in the left DLPFC of men is a screening marker for high-risk groups of men with AD. High ReHo in the right superior marginal gyrus of women is an early warning biomarker for PTSD or depression.

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