{"title":"多靶点多酚类化合物没食子酸乙酯的治疗潜力及药物开发","authors":"Roshni Sharma , Mohammad Adnan Raza , Anjila Firdous , Ajazuddin","doi":"10.1016/j.prenap.2025.100339","DOIUrl":null,"url":null,"abstract":"<div><div>Ethyl gallate, a derivative of gallic acid, having significant characteristics including anti-inflammatory, antioxidant & antiviral, positioning it as potential candidate for therapeutic applications across several different illnesses, such as inflammatory condition, cancer, and viral illnesses like influenza, herpes simplex. Preclinical studies have shown that it has the capacity to modulate inflammation and oxidative stress, both of them plays significant roles in a variety of pathological diseases. The versatility of ethyl gallate in addressing a lot of disease pathways demonstrates its promise in integrated therapeutic methods. However, despite promising in vitro and animal model results, its clinical use remains unknown. The lack of human clinical studies leaves a significant vacuum in our findings, particularly of its safety, efficacy, and comprehensive pharmacological mechanisms. Future study is required to close this gap and establish the therapeutic value of ethyl gallate.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100339"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Therapeutic potential and pharmaceutical development of multitargeted polyphenolic compound ethyl gallate\",\"authors\":\"Roshni Sharma , Mohammad Adnan Raza , Anjila Firdous , Ajazuddin\",\"doi\":\"10.1016/j.prenap.2025.100339\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Ethyl gallate, a derivative of gallic acid, having significant characteristics including anti-inflammatory, antioxidant & antiviral, positioning it as potential candidate for therapeutic applications across several different illnesses, such as inflammatory condition, cancer, and viral illnesses like influenza, herpes simplex. Preclinical studies have shown that it has the capacity to modulate inflammation and oxidative stress, both of them plays significant roles in a variety of pathological diseases. The versatility of ethyl gallate in addressing a lot of disease pathways demonstrates its promise in integrated therapeutic methods. However, despite promising in vitro and animal model results, its clinical use remains unknown. The lack of human clinical studies leaves a significant vacuum in our findings, particularly of its safety, efficacy, and comprehensive pharmacological mechanisms. Future study is required to close this gap and establish the therapeutic value of ethyl gallate.</div></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"8 \",\"pages\":\"Article 100339\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199725001995\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199725001995","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Therapeutic potential and pharmaceutical development of multitargeted polyphenolic compound ethyl gallate
Ethyl gallate, a derivative of gallic acid, having significant characteristics including anti-inflammatory, antioxidant & antiviral, positioning it as potential candidate for therapeutic applications across several different illnesses, such as inflammatory condition, cancer, and viral illnesses like influenza, herpes simplex. Preclinical studies have shown that it has the capacity to modulate inflammation and oxidative stress, both of them plays significant roles in a variety of pathological diseases. The versatility of ethyl gallate in addressing a lot of disease pathways demonstrates its promise in integrated therapeutic methods. However, despite promising in vitro and animal model results, its clinical use remains unknown. The lack of human clinical studies leaves a significant vacuum in our findings, particularly of its safety, efficacy, and comprehensive pharmacological mechanisms. Future study is required to close this gap and establish the therapeutic value of ethyl gallate.