Étienne-Émile鲍留（1929-2025）：类固醇科学家和妇女生育权利的捍卫者。

IF 9.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-08-19 Epub Date: 2025-08-13 DOI:10.1073/pnas.2517065122

Thoru Pederson

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引用次数: 0

摘要

作为一名医生，Étienne-Émile Baulieu很快就把他的重点转向研究，早在他的医学实习。他继续在酮类固醇和其他类固醇，如雌激素，以及它们如何通过受体作用于目标器官，激素与受体结合并激活生理反应方面做出了重大贡献。后来，他咨询了一家法国制药公司，鼓励他们采用他的抗妊娠药概念，这就是标志性的RU-486（米非司酮）。为此，他受到了许多人的赞扬，也受到了其他人的批评。他于2025年5月30日在巴黎郊区的家中去世，享年98岁。在他生命的最后几天，他一直大力支持妇女的生育权利。

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Étienne-Émile Baulieu (1929-2025): Scientist of steroids and champion of women's reproductive rights.

Having trained as a physician, Étienne-Émile Baulieu soon turned his focus to research, as early as his medical internship. He went on to make major contributions on ketosteroids and other steroids, such as estrogen, and how they act on target organs through receptors to which the hormones bind and activate physiological responses. Later, he consulted with a French pharmaceutical company, encouraging them to pursue his concept for an antigestational agent, which became the iconic RU-486 (Mifepristone). For this, he was applauded by many and criticized by others. He died at his home in a suburb of Paris on May 30, 2025, at the age of 98. To his last days, he vigorously maintained his support for women's reproductive rights.

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来源期刊

Proceedings of the National Academy of Sciences of the United States of America 综合性期刊-综合性期刊

CiteScore

19.00

自引率

0.90%

发文量

3575

审稿时长

2.5 months

期刊介绍： The Proceedings of the National Academy of Sciences (PNAS), a peer-reviewed journal of the National Academy of Sciences (NAS), serves as an authoritative source for high-impact, original research across the biological, physical, and social sciences. With a global scope, the journal welcomes submissions from researchers worldwide, making it an inclusive platform for advancing scientific knowledge.