环状rna在结直肠癌中的作用：从分子机制到治疗应用（综述）。

IF 3.9 3区医学 Q2 ONCOLOGY

Oncology reports Pub Date : 2025-11-01 Epub Date: 2025-08-14 DOI:10.3892/or.2025.8972

Yuxing He, Can Luo, Wei Du, Debei Liu, Lingshan Liao, Siqian Wang, Yanlin Cao

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引用次数: 0

摘要

环状RNA （circRNAs）是稳定、保守的非编码RNA分子，在基因调控中起关键作用。由于其组织特异性表达模式和参与各种细胞过程，circRNAs与癌症生物学有关，特别是与结直肠癌（CRC）诊断有关。本文系统探讨了circRNA在结直肠癌发病机制中的作用及其作为结直肠癌诊断生物标志物和治疗靶点的潜力，重点关注了参与结直肠癌发生进展的关键circRNA，其分子机制和临床价值，以及基于circRNA的治疗策略的进展和circRNA应用临床翻译中的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Circular RNAs in colorectal cancer: From molecular mechanisms to therapeutic applications (Review).

Circular RNAs (circRNAs) are stable, conserved non‑coding RNA molecules with key roles in gene regulation. Because of their tissue‑specific expression patterns and involvement in various cellular processes, circRNAs are relevant in cancer biology, specifically for colorectal cancer (CRC) diagnosis. The present review systematically examines the roles of circRNAs in CRC pathogenesis and their potential as diagnostic biomarkers and therapeutic targets for CRC, focusing on the key circRNAs involved in CRC development and progression, their molecular mechanisms and clinical value, as well as advances in circRNA‑based therapeutic strategies and challenges in the clinical translation of circRNA application.

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来源期刊

Oncology reports 医学-肿瘤学

CiteScore

8.50

自引率

2.40%

发文量

187

审稿时长

3 months

期刊介绍： Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.