【关注表达】赖氨酸去甲基化酶2A通过调节PI3K通路和逆转上皮-间质转化促进卵巢癌的进展。

IF 3.9 3区 医学 Q2 ONCOLOGY
Oncology reports Pub Date : 2025-11-01 Epub Date: 2025-08-14 DOI:10.3892/or.2025.8971
Dan-Hua Lu, Jiang Yang, Li-Kun Gao, Jie Min, Jian-Ming Tang, Ming Hu, Yang Li, Su-Ting Li, Jing Chen, Li Hong
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引用次数: 0

摘要

在本文发表后,一位关心的读者引起了编辑的注意,图2D所示的SKOV3实验的一个菌落形成分析图像与图5E所示的“SKOV3/0µM LY294002”图像惊人地相似,如果其中一个盘子旋转90°。在编辑部对本文的数据进行独立分析后,还发现图4E中MMP9印迹(A2780细胞系)的数据与图5B中p - mTOR印迹(同样是A2780细胞系)的数据惊人地相似,这表明其中一个数据组装错误。编辑部联系了作者,要求对本文数据呈现中的这些明显异常进行解释;然而,到目前为止,他们还没有任何回应。由于编辑部已经意识到围绕本文科学完整性的潜在问题,在编辑部继续进一步调查此事的同时,我们发出一份关注表达,通知读者这一潜在问题。[肿瘤杂志]41:917‑927,2019;DOI: 10.3892 / or.2018.6888]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Expression of Concern] Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that one of the colony‑formation assay images shown in Fig. 2D for the SKOV3 experiments was strikingly similar to the 'SKOV3/0 µM LY294002' image shown in Fig. 5E, if one of the dishes were to be rotated 90°. Upon performing an independent analysis of the data in this paper in the Editorial Office, it also came to light that the data shown for the MMP9 blot (A2780 cell line) in Fig. 4E was strikingly similar to the p‑mTOR blot (again for the A2780 cell line) in Fig. 5B, suggesting that one of these figures had been assembled incorrectly. The authors were contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in this paper; however, up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [Oncology Reports 41: 917‑927, 2019; DOI: 10.3892/or.2018.6888].

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来源期刊
Oncology reports
Oncology reports 医学-肿瘤学
CiteScore
8.50
自引率
2.40%
发文量
187
审稿时长
3 months
期刊介绍: Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.
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