艰难梭菌感染的免疫方面及疫苗研制。

IF 4.1 3区医学 Q1 IMMUNOLOGY

Infectious disease clinics of North America Pub Date : 2025-08-12 DOI:10.1016/j.idc.2025.07.008

Rochelle C Glover, F Christopher Peritore-Galve, Borden Lacy, Joseph P Zackular

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引用次数: 0

摘要

艰难梭菌引起抗生素相关性腹泻和假膜性结肠炎。艰难梭菌感染的发病机制是由TcdA和TcdB两种外毒素驱动的，因此它们是治疗干预的优先目标。针对这些毒素的几种疫苗配方已进入3期临床试验，但没有一种成功地阻止了定植或疾病。艰难梭菌发病机制和疫苗学的最新进展使开发有效疫苗的努力重新焕发活力。在这里，我们讨论了基础和临床研究见解，为开发下一代艰难梭菌疫苗提供了一个框架。

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Immune Aspects of Clostridioides difficile Infection and Vaccine Development.

Clostridioides difficile causes antibiotic-associated diarrhea and pseudomembranous colitis. The pathogenesis of C difficile infection is driven by 2 exotoxins, TcdA and TcdB, making them priority targets for therapeutic intervention. Several vaccine formulations targeting these toxins have reached phase 3 clinical trials, but none have successfully prevented colonization or disease. Recent advances in understanding C difficile pathogenesis and vaccinology have revitalized efforts to develop an effective vaccine. Here, we discuss basic and clinical research insights to provide a framework for developing next-generation C difficile vaccines.

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来源期刊

Infectious disease clinics of North America 医学-传染病学

CiteScore

8.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Infectious Disease Clinics of North America updates you on the latest trends in the clinical diagnosis and management of patients with infectious diseases, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in infectious disease, including clinical microbiology, compromised host infections, gastrointestinal infections, global health, hepatitis, HIV/AIDS, hospital-acquired infections, travel medicine, infection control, bacterial infections, sexually transmitted diseases, urinary tract infections, and viral infections.