Hanne Lie Kjærstad, Julian Macoveanu, Alexander Tobias Ysbæk-Nielsen, Viktoria Damgaard, Sophia Frangou, Gitte M. Knudsen, Klara Coello, Sharleny Stanislaus, Maria Faurholt-Jepsen, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
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引用次数: 0
摘要
先前的研究表明，双相情感障碍患者存在脑结构异常和认知困难。虽然有一些证据表明，类似的结构和认知变化也可能存在于双相情感障碍患者的未受影响亲属（UR）中，但尚不清楚它们是保持不变还是随着时间的推移而加剧。在这项研究中，我们研究了UR的认知和大脑结构的纵向轨迹。方法：从UR（72例）和健康对照(HC；n = 65)和随访15（±4）个月时(UR n = 32；HC n = 38)。使用线性混合模型研究了UR和HC在神经认知能力、白质体积、区域皮质灰质（GM）体积和厚度、海马和杏仁核体积以及生物年龄与脑MRI （brainPAD）估计年龄之间的差异。结果：UR表现出轻微的处理速度损伤，在随访时恢复到与HC相当的水平。在两个时间点，与HC相比，UR显示出稳定的杏仁核增大。左侧颞上回GM体积有显著的组-时间交互效应，基线时的UR比HC显示更大的GM体积，随时间归一化。UR组与HC组在脑pad中的差异无统计学意义。结论：与HC相比，UR的双侧杏仁核增大和颞叶GM体积增大可能反映了双相情感障碍的易感因素。需要更长的随访时间来阐明随后发病风险的结构性预测因素。
Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First-Degree Relatives of Patients With Bipolar Disorder
Introduction
Prior research suggests structural brain abnormalities and cognitive difficulties in patients with bipolar disorder. Although there is some evidence that similar structural and cognitive changes may also be present in unaffected relatives (UR) of patients with bipolar disorder, it is not known whether they remain static or aggravate over time. In this study, we investigate the longitudinal trajectories of cognition and brain structure in UR.
Methods
Longitudinal neurocognitive and MRI data were acquired at baseline from UR (n = 72) and healthy controls (HC; n = 65) and at 15 (±4) months follow-up (UR n = 32; HC n = 38). The differential trajectories between UR and HC in neurocognitive performance, white matter volume, regional cortical gray matter (GM) volume and thickness, hippocampal and amygdala volumes, and the difference between biological age and age estimated from brain MRI (brainPAD) were investigated using linear mixed models.
Results
UR showed subtle impairments in processing speed, which normalized at follow-up to levels comparable to HC. At both time points, UR showed stable enlargement of amygdalae compared to HC. There was a significant group-by-time interaction effect for the GM volume in the left superior temporal gyrus, driven by UR at baseline displaying larger GM volume compared to HC, which normalized over time. There was no significant difference between UR and HC in brainPAD.
Conclusion
Bilaterally enlarged amygdala and larger temporal GM volume in UR compared to HC may reflect a vulnerability factor for bipolar disorder. Longer follow-up times are needed to elucidate structural predictors of risk of subsequent illness onset.
期刊介绍：
Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas:
biochemistry
physiology
neuropsychopharmacology
neuroanatomy
neuropathology
genetics
brain imaging
epidemiology
phenomenology
clinical aspects
and therapeutics of bipolar disorders
Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders.
The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.
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