多组学研究揭示了过量饲养前后朗德鹅肝脏脂质代谢的变化。

IF 2.5 2区 农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Weiqing Ma, Liu Yang, Yadi Jing, Pengwei Ren, Xiang Liu, Meixia Zhang, Xiaomin Qi, Mingxia Zhu, Qiaomei Zhang
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引用次数: 0

摘要

目的:本试验旨在通过组学测序综合生产指标,阐明过量饲养过程中肝脏代谢与肠道菌群之间的系统性扰动。方法:选取120只7周龄雄性朗德鹅,在围栏环境下进行地板饲养。第8周开始过量饲养,使用含5%大豆油的玉米基饲粮。饲喂方案最初为每日3餐(150 ~ 180 g/餐),2周后逐渐增加至每日5餐(300 ~ 500 g/餐),并维持4周的总过饲期。结果:结果表明,过度喂养显著增加了肝脏重量和血脂水平,并伴有细胞内脂滴积累。同时,牛磺酸偶联胆汁酸的下调和游离胆汁酸的上调破坏了胆固醇的稳态。至关重要的是,过度喂养引发肠道微生物失调,其特征是埃希菌-志贺氏菌富集和norank_o_Clostridia_UCG-014耗竭。结论:“肠道微生物-胆汁酸-肝轴”的鉴定可能是导致过量饲养诱导鹅肝形成的关键信号通路,同时为过量饲养策略减轻水禽生产中的代谢病理提供理论基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multiomics reveals changes in lipid metabolism in the livers of landes geese before and after overfeeding.

Objective: : The aim of this experiment was to integrated production indices with omics sequencing to elucidate the systemic perturbations between hepatic metabolism and the gut microbiota during overfeeding.

Methods: : A total of 120 seven-week-old male Landes geese were floor reared in a pen environment. Overfeeding commenced at week 8 using a corn-based diet containing 5% soybean oil. The feeding regimen consisted of three daily meals (150-180 g/meal) initially, gradually increasing to five meals (300-500 g/meal) after two weeks, and was maintained for a total overfeeding period of four weeks.

Results: : The results demonstrated that overfeeding significantly increased liver weight and serum lipid levels, accompanied by intracellular lipid droplet accumulation. Concurrently, the downregulation of taurine-conjugated bile acids and the upregulation of free bile acids disrupted cholesterol homeostasis. Crucially, overfeeding triggered gut microbial dysbiosis characterized by Escherichia-Shigella enrichment and norank_o_Clostridia_UCG-014 depletion.

Conclusion: : Our work demonstrated that the identification of the "gut microbiota‒bile acid‒liver axis" could as a pivotal signaling pathway driving overfeeding-induced foie gras formation while providing a theoretical foundation for overfeeding strategies to mitigate metabolic pathologies in waterfowl production.

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来源期刊
Animal Bioscience
Animal Bioscience AGRICULTURE, DAIRY & ANIMAL SCIENCE-
CiteScore
5.00
自引率
0.00%
发文量
223
审稿时长
3 months
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