{"title":"裁剪静电纺聚乳酸纳米纤维的持续药物释放和控制交付应用","authors":"Anshuman Gupta, Vishwanath Gholap, Balasubramanian Kandasubramanian","doi":"10.1007/s10965-025-04521-x","DOIUrl":null,"url":null,"abstract":"<div><p>The demand for sustainable drug delivery systems has driven research into biodegradable polymers with improved performance characteristics. Polylactic acid (PLA), a biocompatible and FDA-approved polymer, holds promise in biomedical applications but is limited by slow degradation rates and insufficient antimicrobial activity. This study develops electrospun PLA nanofibers infused with Tulsi (Ocimum sanctum) essential oil to improve sustained drug release, antimicrobial activity, and biodegradability. Physicochemical properties analyzed using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and contact angle measurements revealed smooth morphology and increased hydrophobicity (88.4°). Drug release kinetics modeled using Korsmeyer-Peppas equations indicated a diffusion-controlled mechanism with R² value of 0.8022, enabling sustained release over 30 days. The nanofibers exhibited antibacterial efficacy against Escherichia coli and Staphylococcus aureus with inhibition zones of 1.2 cm and antifungal activity against Aspergillus niger with zones up to 1.0 cm. Degradation studies revealed accelerated biodegradation, with 81.4% weight loss in 30 days under simulated environmental conditions. These results showcase the multifunctional performance of Tulsi-infused PLA nanofibers, offering sustained drug release, antimicrobial activity, and eco-friendly degradation. This study highlights their potential for biomedical applications, such as wound dressings and antimicrobial coatings, while paving the way for advanced polymer systems and dual-drug delivery strategies.</p><h3>Graphical Abstract</h3><p>The graphical abstract depicts the synthesis of electrospun polylactic acid (PLA) nanofibers functionalized with Tulsi essential oil. Starting from PLA pellets, the electrospinning process yields nanofibers with enhanced antimicrobial activity and sustained drug release properties. Fourier-transform infrared (FTIR) spectroscopy confirms the successful encapsulation of Germacrene D. These nanofibers demonstrate potential applications in wound dressings, antimicrobial coatings, and environmentally sustainable biomedical systems.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":658,"journal":{"name":"Journal of Polymer Research","volume":"32 8","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tailoring electrospun polylactic acid nanofibers for sustained drug release and controlled delivery applications\",\"authors\":\"Anshuman Gupta, Vishwanath Gholap, Balasubramanian Kandasubramanian\",\"doi\":\"10.1007/s10965-025-04521-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The demand for sustainable drug delivery systems has driven research into biodegradable polymers with improved performance characteristics. Polylactic acid (PLA), a biocompatible and FDA-approved polymer, holds promise in biomedical applications but is limited by slow degradation rates and insufficient antimicrobial activity. This study develops electrospun PLA nanofibers infused with Tulsi (Ocimum sanctum) essential oil to improve sustained drug release, antimicrobial activity, and biodegradability. Physicochemical properties analyzed using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and contact angle measurements revealed smooth morphology and increased hydrophobicity (88.4°). Drug release kinetics modeled using Korsmeyer-Peppas equations indicated a diffusion-controlled mechanism with R² value of 0.8022, enabling sustained release over 30 days. The nanofibers exhibited antibacterial efficacy against Escherichia coli and Staphylococcus aureus with inhibition zones of 1.2 cm and antifungal activity against Aspergillus niger with zones up to 1.0 cm. Degradation studies revealed accelerated biodegradation, with 81.4% weight loss in 30 days under simulated environmental conditions. These results showcase the multifunctional performance of Tulsi-infused PLA nanofibers, offering sustained drug release, antimicrobial activity, and eco-friendly degradation. This study highlights their potential for biomedical applications, such as wound dressings and antimicrobial coatings, while paving the way for advanced polymer systems and dual-drug delivery strategies.</p><h3>Graphical Abstract</h3><p>The graphical abstract depicts the synthesis of electrospun polylactic acid (PLA) nanofibers functionalized with Tulsi essential oil. Starting from PLA pellets, the electrospinning process yields nanofibers with enhanced antimicrobial activity and sustained drug release properties. Fourier-transform infrared (FTIR) spectroscopy confirms the successful encapsulation of Germacrene D. These nanofibers demonstrate potential applications in wound dressings, antimicrobial coatings, and environmentally sustainable biomedical systems.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":658,\"journal\":{\"name\":\"Journal of Polymer Research\",\"volume\":\"32 8\",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Polymer Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10965-025-04521-x\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymer Research","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10965-025-04521-x","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Tailoring electrospun polylactic acid nanofibers for sustained drug release and controlled delivery applications
The demand for sustainable drug delivery systems has driven research into biodegradable polymers with improved performance characteristics. Polylactic acid (PLA), a biocompatible and FDA-approved polymer, holds promise in biomedical applications but is limited by slow degradation rates and insufficient antimicrobial activity. This study develops electrospun PLA nanofibers infused with Tulsi (Ocimum sanctum) essential oil to improve sustained drug release, antimicrobial activity, and biodegradability. Physicochemical properties analyzed using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and contact angle measurements revealed smooth morphology and increased hydrophobicity (88.4°). Drug release kinetics modeled using Korsmeyer-Peppas equations indicated a diffusion-controlled mechanism with R² value of 0.8022, enabling sustained release over 30 days. The nanofibers exhibited antibacterial efficacy against Escherichia coli and Staphylococcus aureus with inhibition zones of 1.2 cm and antifungal activity against Aspergillus niger with zones up to 1.0 cm. Degradation studies revealed accelerated biodegradation, with 81.4% weight loss in 30 days under simulated environmental conditions. These results showcase the multifunctional performance of Tulsi-infused PLA nanofibers, offering sustained drug release, antimicrobial activity, and eco-friendly degradation. This study highlights their potential for biomedical applications, such as wound dressings and antimicrobial coatings, while paving the way for advanced polymer systems and dual-drug delivery strategies.
Graphical Abstract
The graphical abstract depicts the synthesis of electrospun polylactic acid (PLA) nanofibers functionalized with Tulsi essential oil. Starting from PLA pellets, the electrospinning process yields nanofibers with enhanced antimicrobial activity and sustained drug release properties. Fourier-transform infrared (FTIR) spectroscopy confirms the successful encapsulation of Germacrene D. These nanofibers demonstrate potential applications in wound dressings, antimicrobial coatings, and environmentally sustainable biomedical systems.
期刊介绍：
Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology.
As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including:
polymer synthesis;
polymer reactions;
polymerization kinetics;
polymer physics;
morphology;
structure-property relationships;
polymer analysis and characterization;
physical and mechanical properties;
electrical and optical properties;
polymer processing and rheology;
application of polymers;
supramolecular science of polymers;
polymer composites.
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