Panpan Dong, Fang Li, Zijian Wu, Lu Xue, Mingming Luo, Yijun Tan, Haitao Li, Xu Yang
{"title":"液体剥脱石墨烯/Ti3C2 MXene复合传感器用于牛奶和蜂蜜中氯霉素的超灵敏电化学检测","authors":"Panpan Dong, Fang Li, Zijian Wu, Lu Xue, Mingming Luo, Yijun Tan, Haitao Li, Xu Yang","doi":"10.1007/s12161-025-02856-1","DOIUrl":null,"url":null,"abstract":"<div><p>The presence of chloramphenicol (CAP) residues in animal-derived foods has the potential to accumulate in the human body during metabolism, which can result in adverse effects on human health. Herein, a novel ultrasensitive detection platform based on liquid exfoliated graphene (LEG)/Ti<sub>3</sub>C<sub>2</sub> MXene nanocomposites modified indium tin oxide (ITO) electrode (LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO), is proposed for the detection of CAP. The embedding of LEG into Ti<sub>3</sub>C<sub>2</sub> MXene can suppress the aggregation of Ti<sub>3</sub>C<sub>2</sub> MXene flakes, which has been proven to be an effective method for improving sensing performance due to its advantages of higher specific surface area and electron transfer efficiency. The CAP-specific aptamer is immobilized on LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO through π-π adsorption as the bio-recognition element. Differential pulse voltammograms are utilized to analyze the changes in peak current of the modified electrode before and after the interaction between the immobilized aptamer and CAP, achieving quantitative measurement of CAP. The prepared aptamer/LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO sensor has allowed the linear concentration range of CAP from 0.001 pM to10 μM, with a limit of detection (LOD) of 0.485 fM. The sensor performs well in stability, reproducibility, and selectivity. Additionally, it is demonstrated successfully to detect CAP in the spiked samples of milk and honey.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":561,"journal":{"name":"Food Analytical Methods","volume":"18 9","pages":"2063 - 2075"},"PeriodicalIF":3.0000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Liquid Exfoliated Graphene/Ti3C2 MXene Composite Based Aptasensor for Ultrasensitive Electrochemical Detection of Chloramphenicol in Milk and Honey\",\"authors\":\"Panpan Dong, Fang Li, Zijian Wu, Lu Xue, Mingming Luo, Yijun Tan, Haitao Li, Xu Yang\",\"doi\":\"10.1007/s12161-025-02856-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The presence of chloramphenicol (CAP) residues in animal-derived foods has the potential to accumulate in the human body during metabolism, which can result in adverse effects on human health. Herein, a novel ultrasensitive detection platform based on liquid exfoliated graphene (LEG)/Ti<sub>3</sub>C<sub>2</sub> MXene nanocomposites modified indium tin oxide (ITO) electrode (LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO), is proposed for the detection of CAP. The embedding of LEG into Ti<sub>3</sub>C<sub>2</sub> MXene can suppress the aggregation of Ti<sub>3</sub>C<sub>2</sub> MXene flakes, which has been proven to be an effective method for improving sensing performance due to its advantages of higher specific surface area and electron transfer efficiency. The CAP-specific aptamer is immobilized on LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO through π-π adsorption as the bio-recognition element. Differential pulse voltammograms are utilized to analyze the changes in peak current of the modified electrode before and after the interaction between the immobilized aptamer and CAP, achieving quantitative measurement of CAP. The prepared aptamer/LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO sensor has allowed the linear concentration range of CAP from 0.001 pM to10 μM, with a limit of detection (LOD) of 0.485 fM. The sensor performs well in stability, reproducibility, and selectivity. Additionally, it is demonstrated successfully to detect CAP in the spiked samples of milk and honey.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":561,\"journal\":{\"name\":\"Food Analytical Methods\",\"volume\":\"18 9\",\"pages\":\"2063 - 2075\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Analytical Methods\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12161-025-02856-1\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Analytical Methods","FirstCategoryId":"97","ListUrlMain":"https://link.springer.com/article/10.1007/s12161-025-02856-1","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Liquid Exfoliated Graphene/Ti3C2 MXene Composite Based Aptasensor for Ultrasensitive Electrochemical Detection of Chloramphenicol in Milk and Honey
The presence of chloramphenicol (CAP) residues in animal-derived foods has the potential to accumulate in the human body during metabolism, which can result in adverse effects on human health. Herein, a novel ultrasensitive detection platform based on liquid exfoliated graphene (LEG)/Ti3C2 MXene nanocomposites modified indium tin oxide (ITO) electrode (LEG/Ti3C2 MXene/ITO), is proposed for the detection of CAP. The embedding of LEG into Ti3C2 MXene can suppress the aggregation of Ti3C2 MXene flakes, which has been proven to be an effective method for improving sensing performance due to its advantages of higher specific surface area and electron transfer efficiency. The CAP-specific aptamer is immobilized on LEG/Ti3C2 MXene/ITO through π-π adsorption as the bio-recognition element. Differential pulse voltammograms are utilized to analyze the changes in peak current of the modified electrode before and after the interaction between the immobilized aptamer and CAP, achieving quantitative measurement of CAP. The prepared aptamer/LEG/Ti3C2 MXene/ITO sensor has allowed the linear concentration range of CAP from 0.001 pM to10 μM, with a limit of detection (LOD) of 0.485 fM. The sensor performs well in stability, reproducibility, and selectivity. Additionally, it is demonstrated successfully to detect CAP in the spiked samples of milk and honey.
期刊介绍：
Food Analytical Methods publishes original articles, review articles, and notes on novel and/or state-of-the-art analytical methods or issues to be solved, as well as significant improvements or interesting applications to existing methods. These include analytical technology and methodology for food microbial contaminants, food chemistry and toxicology, food quality, food authenticity and food traceability. The journal covers fundamental and specific aspects of the development, optimization, and practical implementation in routine laboratories, and validation of food analytical methods for the monitoring of food safety and quality.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
