环糊精作为精确肿瘤化疗的纳米级药物传递系统的多功能超分子构建块

IF 8.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chinese Chemical Letters Pub Date : 2025-06-03 DOI:10.1016/j.cclet.2025.111406

Peng Liu

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引用次数: 0

摘要

纳米给药系统（Nanoscale drug - delivery systems, nano- dds）在肿瘤化疗领域引起了广泛的关注，以提高抗肿瘤疗效，减少毒副作用。环糊精作为一种多功能的超分子材料，在智能纳米dds的制备中得到了广泛的应用。除了其多功能性使其成为胶束纳米药物的星形（co）聚合物的多功能核心外，通过其疏水腔的特异性主客体包合作用赋予其多种功能：(i)胶束纳米药物的两亲共聚物设计，（ii）超分子水凝胶和聚（伪）轮烷纳米水凝胶作为药物载体，以及（iii）直接和间接载药的受体。本文综述了近年来肿瘤化疗中CD在纳米dds中的研究进展，并对CD单元的重要作用进行了分类。基于结构-性能关系，提出了未来发展的展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cyclodextrins as versatile supramolecular building block in nanoscale drug delivery systems for precise tumor chemotherapy

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Cyclodextrins as versatile supramolecular building block in nanoscale drug delivery systems for precise tumor chemotherapy

Nanoscale drug delivery systems (nano-DDSs) have attracted intense interest in tumor chemotherapy in the last decades, to improve antitumor efficacy and minimize toxic and side effects. As a versatile supramolecular building block, cyclodextrins (CDs) have been widely used in the fabrication of the smart nano-DDSs. Besides their multifunctionality, which makes them versatile core in the star (co)polymers for micellar nanomedicines, specific host-guest inclusion complexation via their hydrophobic cavities endows them diversified functions: (i) design of amphiphilic copolymers for micellar nanomedicines, (ii) supramolecular hydrogels and poly(pseudo)rotaxane nano-hydrogels as drug carriers, and (iii) recipient for direct and indirect drug-loading. In the present work, the recent progress of CDs in nano-DDSs for tumor chemotherapy was reviewed, classified by the crucial roles of CD units. Based on the structure-performance relationship, the future perspective was also proposed.

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来源期刊

Chinese Chemical Letters 化学-化学综合

CiteScore

14.10

自引率

15.40%

发文量

8969

审稿时长

1.6 months

期刊介绍： Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.