铝工人血清金属水平和NLRP3基因多态性与认知功能的关系：一项流行病学和遗传学的联合研究

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-08-12 DOI:10.1016/j.jtemb.2025.127712

Youxing Li , Wenxue Li , Yaqin Pang , Yufang Cen , Rongqing Xiao , Yinxia Lin , Boya Li , Jingyi Lu , Yincai Lan , Ahmad Razali Bin Ishak , Guangzi Qi , Mohd Shukri Bin Mohd Aris

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引用次数: 0

摘要

金属、基因和认知功能密切相关。本研究评估了铝工人血清金属水平、NLRP3基因多态性及其与认知功能的关系。方法对478名铝厂工人进行横断面调查。采用电感耦合等离子体质谱（ICP-MS）测定血清金属水平，采用蒙特利尔认知评估（MoCA）量表评估认知功能。采用广义线性模型（GLM）、最小绝对收缩和选择算子（Lasso）回归、贝叶斯核机回归（BKMR）和加权分位数和（WQS）分析金属暴露与认知功能之间的关系，以及与NLRP3基因多态性的相互作用。结果锌（Zn）水平与MoCA评分呈正相关（β= 4.73, 95 % CI: 0.54, 8.92）。低于60百分位的金属混合物（Na, Zn, Co, Mo, Ti, Sr, Ba）也与MoCA分数呈正相关。NLRP3 rs3806265C/C和rs4612666C/T和T/T基因型与MoCA评分呈负相关(β= - 0.91, 95 % CI: - 1.64, - 0.17；β= - 0.61, 95 % ci: - 1.19, - 0.02；β= - 0.86, 95 % ci: - 1.62, - 0.10)。在C/T基因型rs3806265和rs4612666的个体中，Zn与MoCA评分呈正相关(β= 5.99, 95 % CI: 0.60, 11.38；β= 6.46, 95 % ci: 0.80, 12.12)。结论血清锌水平降低可能增加认知功能障碍风险。携带NLRP3基因rs3806265C/C和rs4612666C/T或T/T的个体更容易出现认知能力下降。携带rs3806265C/T和rs4612666C/T基因型的个体在锌缺乏的情况下更容易导致认知能力下降。

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Association between serum metal levels and NLRP3 gene polymorphisms with cognitive function in aluminum workers: A combined epidemiological and genetic study

Background

Metals, genes, and cognitive function are closely related. This study evaluated serum metal levels, NLRP3 gene polymorphisms, and their association with cognitive function in aluminum workers.

Methods

A cross-sectional survey was conducted with 478 aluminum workers. Serum metal levels were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), and cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale. Generalized Linear Models (GLM), Least absolute shrinkage and selection operator (Lasso) regression, Bayesian Kernel Machine Regression (BKMR), and Weighted Quantile Sum (WQS) were used to analyze the relationship between metal exposure, cognitive function, and the interaction with NLRP3 gene polymorphisms.

Results

Zinc (Zn) levels were positively associated with MoCA scores (β= 4.73, 95 % CI: 0.54, 8.92). A metal mixture (Na, Zn, Co, Mo, Ti, Sr, Ba) below the 60th percentile also showed a positive correlation with MoCA scores. The NLRP3 rs3806265C/C and rs4612666C/T and T/T genotypes were negatively associated with MoCA scores (β= −0.91, 95 % CI: −1.64, −0.17; β= −0.61, 95 % CI: −1.19, −0.02; β= −0.86, 95 % CI: −1.62, −0.10). In individuals with the C/T genotype of rs3806265 and rs4612666, Zn was positively associated with MoCA scores (β= 5.99, 95 % CI: 0.60, 11.38; β= 6.46, 95 % CI: 0.80, 12.12).

Conclusion

Decreased serum Zn levels may increase cognitive dysfunction risk. Individuals carrying the NLRP3 rs3806265C/C and rs4612666C/T or T/T more susceptible to cognitive decline. Individuals carrying the rs3806265C/T and rs4612666C/T genotypes are more likely to cause cognitive decline in the presence of Zn deficiency.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.