二氧化碳脑血管反应性(CVR)对咖啡因的依赖性。

Imaging neuroscience (Cambridge, Mass.) Pub Date : 2025-08-08 eCollection Date: 2025-01-01 DOI:10.1162/IMAG.a.103
Dinil Sasi Sankaralayam, Cuimei Xu, Zhiyi Hu, Abhay Moghekar, Dengrong Jiang, Chen Hu, Peiying Liu, Hanzhang Lu
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引用次数: 0

摘要

脑血管反应性(CVR)是脑血管健康的重要标志,特别是在小血管和大血管疾病的情况下。然而,该测量的一个不希望的特征是个体之间的CVR值存在很大差异,这主要归因于生理因素。在这里,我们验证了一个假设,即咖啡因,一种广泛使用的神经兴奋剂,对MRI测量的CVR有显著影响。16名年轻健康的参与者被招募,并根据他们的咖啡因消费习惯分为咖啡因幼稚组(N = 8)和咖啡因习惯组(N = 8)。采用两种不同的MRI方法,即相对比(PC)脑血流量(CBF)和T2*-EPI血氧水平依赖(BOLD)-MRI,通过CO2吸入评估CVR。每个参与者都接受了两次核磁共振检查,一次是在口服200毫克咖啡因之前,另一次是在口服200毫克咖啡因之后。此外,使用t2 - relax - under - spin - tagging (TRUST) MRI测量静脉氧合(Yv)。对于基础生理参数,在初始组(p = 0.002)和习惯组(p < 0.001)中均观察到咖啡因诱导的CBF显著降低。咖啡因未接触组的基础脑血流减少了31.2±14.1%,而咖啡因习惯组的基础脑血流减少了16.7±5.0%,组间差异有统计学意义(p = 0.04)。在基础Yv中也有类似的观察结果,未接触咖啡因的参与者(21.5±8.9%)比习惯参与者(7.6±10.1%)的降低幅度更大(p = 0.02)。两组的CBF- cvr均显著降低:咖啡因初始组从4.5±0.9 CBF/mmHg降至3.0±0.9% CBF/mmHg(33.3±14.1%,p < 0.001),咖啡因习惯组从5.1±1.5 CBF/mmHg降至3.7±1.3% CBF/mmHg(27.3±16.0%,p = 0.009)。两组间CVR降低程度无显著差异(p = 0.23)。服用咖啡因后BOLD-CVR有适度降低,从0.17±0.04% /mmHg降至0.15±0.05% /mmHg(14.1±16.8%,p = 0.02)。在摄入咖啡因后BOLD-CVR的降低方面,两组参与者之间没有差异。这项研究表明,使用CVR作为疾病标志物的调查可能受益于考虑参与者的咖啡因摄入量和/或其血液浓度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The dependence of CO2 cerebrovascular reactivity (CVR) on caffeine.

Cerebrovascular reactivity (CVR) represents an important marker of brain vascular health, particularly in the context of small and large vessel diseases. However, an undesired feature of this measure is that there exist large variations in CVR values across individuals, which is mainly attributed to physiological factors. Here, we test the hypothesis that caffeine, a widely consumed neurostimulant, has a significant effect on CVR measured with MRI. Sixteen young healthy participants were enrolled and categorized into caffeine-naive (N = 8) and caffeine-habituated (N = 8) groups based on their caffeine consumption habits. CVR was assessed via CO2 inhalation using two different MRI methods, phase-contrast (PC) cerebral blood flow (CBF), and T2*-EPI Blood-Oxygenation-Level-Dependent (BOLD)-MRI. Each participant underwent two MRI sessions, one before and the other after an oral administration of 200 mg of caffeine. Additionally, venous oxygenation (Yv) was measured using T2-Relaxation-Under-Spin-Tagging (TRUST) MRI. For basal physiological parameters, a significant caffeine-induced CBF decrease was observed in both naive (p = 0.002) and habituated (p < 0.001) groups. The caffeine-naive group exhibited a 31.2 ± 14.1% reduction in basal CBF, whereas the caffeine-habituated group showed a 16.7 ± 5.0% reduction, revealing significant differences between groups (p = 0.04). A similar observation was seen in basal Yv, with caffeine-naive participants showing a greater (p = 0.02) reduction (21.5 ± 8.9%) than the habituated participants (7.6 ± 10.1%). CBF-CVR decreased significantly in both groups: from 4.5 ± 0.9 to 3.0 ± 0.9 %CBF/mmHg of CO2 (33.3 ± 14.1%, p < 0.001) in the caffeine-naive group, and from 5.1 ± 1.5 to 3.7 ± 1.3 %CBF/mmHg of CO2 (27.3 ± 16.0%, p = 0.009) in the caffeine-habituated group. No significant differences were observed between groups in terms of the extent of CVR reduction (p = 0.23). BOLD-CVR showed modest reduction after caffeine administration, from 0.17 ± 0.04 %/mmHg to 0.15 ± 0.05 %/mmHg (14.1 ± 16.8%, p = 0.02). There was no difference between the participant groups in terms of BOLD-CVR reduction following caffeine consumption. This study suggests that investigations using CVR as a disease marker may benefit from accounting for the caffeine consumption and/or its blood concentration in the participants.

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