功能MRI显示纵向局灶性高密度θ波爆发刺激(hdTBS)后大鼠脑活动的区域变化。

Imaging neuroscience (Cambridge, Mass.) Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI:10.1162/IMAG.a.92
Charlotte Qiong Li, Samantha Hoffman, Hieu Nguyen, Antonia Vrana, Aidan Carney, Ying Duan, Zilu Ma, Nanyin Zhang, Yihong Yang, Hanbing Lu
{"title":"功能MRI显示纵向局灶性高密度θ波爆发刺激(hdTBS)后大鼠脑活动的区域变化。","authors":"Charlotte Qiong Li, Samantha Hoffman, Hieu Nguyen, Antonia Vrana, Aidan Carney, Ying Duan, Zilu Ma, Nanyin Zhang, Yihong Yang, Hanbing Lu","doi":"10.1162/IMAG.a.92","DOIUrl":null,"url":null,"abstract":"<p><p>The therapeutic benefits of transcranial magnetic stimulation (TMS) are believed to stem from neuroplasticity induced by repeated sessions. While animal models have contributed to our understanding of TMS-induced plasticity, there is a need for a rodent model that closely replicates the prolonged conditions experienced by humans. This study aimed to develop a rat model that reflects the spatial and temporal dynamics of human TMS protocols and to evaluate the carryover effects of TMS on the brain at a systems level. Experiments were carried out on two groups of rats (N = 33). In the first cohort, rats were implanted with microwire electrodes to record motor-evoked potential (MEP) signals and received daily sessions of high-density theta burst stimulation (hdTBS) for 5 days. Cortical excitability was assessed through input-output (I-O) curves before and after hdTBS (Day 0 and Day 6). To identify brain regions affected by the longitudinal TMS, the second cohort underwent identical TMS protocol and received fMRI scans on Days 0 and 6 to measure basal cerebral blood volume (CBV). Results reveal that daily hdTBS significantly shifted I-O curves upward in the TMS group (N = 9) compared to the sham group (N = 7), reflecting enhanced cortical excitability. Additionally, fMRI data showed elevated basal CBV in both the stimulation sites and in the connected networks (N = 8 for active TMS and N = 9 for sham), suggesting increased basal metabolism. This study opens a novel platform for further exploring the mechanisms underlying TMS-induced plasticity.</p>","PeriodicalId":73341,"journal":{"name":"Imaging neuroscience (Cambridge, Mass.)","volume":"3 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330834/pdf/","citationCount":"0","resultStr":"{\"title\":\"Functional MRI reveals regional changes of brain activity in rats following longitudinal focal high-density theta burst stimulation (hdTBS).\",\"authors\":\"Charlotte Qiong Li, Samantha Hoffman, Hieu Nguyen, Antonia Vrana, Aidan Carney, Ying Duan, Zilu Ma, Nanyin Zhang, Yihong Yang, Hanbing Lu\",\"doi\":\"10.1162/IMAG.a.92\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The therapeutic benefits of transcranial magnetic stimulation (TMS) are believed to stem from neuroplasticity induced by repeated sessions. While animal models have contributed to our understanding of TMS-induced plasticity, there is a need for a rodent model that closely replicates the prolonged conditions experienced by humans. This study aimed to develop a rat model that reflects the spatial and temporal dynamics of human TMS protocols and to evaluate the carryover effects of TMS on the brain at a systems level. Experiments were carried out on two groups of rats (N = 33). In the first cohort, rats were implanted with microwire electrodes to record motor-evoked potential (MEP) signals and received daily sessions of high-density theta burst stimulation (hdTBS) for 5 days. Cortical excitability was assessed through input-output (I-O) curves before and after hdTBS (Day 0 and Day 6). To identify brain regions affected by the longitudinal TMS, the second cohort underwent identical TMS protocol and received fMRI scans on Days 0 and 6 to measure basal cerebral blood volume (CBV). Results reveal that daily hdTBS significantly shifted I-O curves upward in the TMS group (N = 9) compared to the sham group (N = 7), reflecting enhanced cortical excitability. Additionally, fMRI data showed elevated basal CBV in both the stimulation sites and in the connected networks (N = 8 for active TMS and N = 9 for sham), suggesting increased basal metabolism. This study opens a novel platform for further exploring the mechanisms underlying TMS-induced plasticity.</p>\",\"PeriodicalId\":73341,\"journal\":{\"name\":\"Imaging neuroscience (Cambridge, Mass.)\",\"volume\":\"3 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330834/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Imaging neuroscience (Cambridge, Mass.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1162/IMAG.a.92\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Imaging neuroscience (Cambridge, Mass.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1162/IMAG.a.92","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

经颅磁刺激(TMS)的治疗效益被认为源于反复治疗引起的神经可塑性。虽然动物模型有助于我们理解经颅磁刺激诱导的可塑性,但仍需要一种啮齿类动物模型来密切复制人类所经历的长期条件。本研究旨在建立一个大鼠模型,以反映人类经颅磁刺激方案的时空动态,并在系统水平上评估经颅磁刺激对大脑的传导效应。实验采用两组大鼠(N = 33)进行。在第一组实验中,大鼠植入微丝电极记录运动诱发电位(MEP)信号,并连续5天每天接受高密度θ波爆发刺激(hdTBS)。通过hdTBS前后(第0天和第6天)的输入-输出(I-O)曲线评估皮质兴奋性。为了确定受纵向经颅磁刺激影响的大脑区域,第二组受试者在第0天和第6天接受相同的经颅磁刺激方案和功能磁共振成像扫描,以测量基础脑血容量(CBV)。结果显示,与假手术组(N = 7)相比,经颅磁刺激组(N = 9)每日hdTBS显著使I-O曲线向上移动,反映了皮质兴奋性增强。此外,fMRI数据显示刺激部位和连接网络的基础CBV均升高(激活TMS N = 8,假性TMS N = 9),表明基础代谢增加。本研究为进一步探索经颅磁刺激诱导的可塑性机制提供了一个新的平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional MRI reveals regional changes of brain activity in rats following longitudinal focal high-density theta burst stimulation (hdTBS).

The therapeutic benefits of transcranial magnetic stimulation (TMS) are believed to stem from neuroplasticity induced by repeated sessions. While animal models have contributed to our understanding of TMS-induced plasticity, there is a need for a rodent model that closely replicates the prolonged conditions experienced by humans. This study aimed to develop a rat model that reflects the spatial and temporal dynamics of human TMS protocols and to evaluate the carryover effects of TMS on the brain at a systems level. Experiments were carried out on two groups of rats (N = 33). In the first cohort, rats were implanted with microwire electrodes to record motor-evoked potential (MEP) signals and received daily sessions of high-density theta burst stimulation (hdTBS) for 5 days. Cortical excitability was assessed through input-output (I-O) curves before and after hdTBS (Day 0 and Day 6). To identify brain regions affected by the longitudinal TMS, the second cohort underwent identical TMS protocol and received fMRI scans on Days 0 and 6 to measure basal cerebral blood volume (CBV). Results reveal that daily hdTBS significantly shifted I-O curves upward in the TMS group (N = 9) compared to the sham group (N = 7), reflecting enhanced cortical excitability. Additionally, fMRI data showed elevated basal CBV in both the stimulation sites and in the connected networks (N = 8 for active TMS and N = 9 for sham), suggesting increased basal metabolism. This study opens a novel platform for further exploring the mechanisms underlying TMS-induced plasticity.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信