上颌第二磨牙根融合:ICR小鼠牙槽骨丢失的发生率及其与牙槽骨丢失的关系。

IF 3.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Yerim Oh, Bo Hyun Jung, Ki-Yeon Yoo, In-Kyung Hwang, Jong-Bin Lee, Heung-Sik Um, Jae-Kwan Lee
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引用次数: 0

摘要

目的:磨牙根融合是一种常见的根形态变异,已知对牙周病的预后有不利影响。在动物模型的实验性牙周病诱导方法中,结扎性牙周炎(LIP)小鼠模型是最常用的方法。然而,很少有研究检查实验小鼠的根异常。本研究旨在探讨小鼠上颌第二磨牙牙根融合的发生率及其与牙槽骨丢失的关系,为动物LIP模型的建立提供新的思路。方法:对2019年至2024年2月在江陵原州大学牙科学院牙周病科和解剖系进行的牙周炎实验中作为对照动物的癌症研究所小鼠222只(上颌第二磨牙444颗)进行初步检查。在排除骨折或缺失牙齿后,402颗牙齿被纳入最终分析。使用微型计算机断层扫描评估根融合并根据融合程度进行分类。为了研究融合根与牙槽骨丢失的关系,我们在上颌第二磨牙的中、远侧测量了牙髓-牙釉质连接处到牙槽骨嵴的距离。结果:10.4%的动物和6.5%的牙根融合。观察到两种类型的融合:中腭(MP)和腭后腭。部分根融合比完全根融合更常见。在结扎组中,MP融合的牙齿比没有根融合的牙齿表现出更大的牙槽骨丢失(结论:在本研究的局限性内,在LIP小鼠模型中,上颌第二磨牙MP根融合加速了结扎牙齿的牙槽骨丢失。未来的研究应考虑中枢性牙根融合引起的偏差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Maxillary second molar root fusion: incidence and relationship with alveolar bone loss in ICR mice.

Purpose: Fusion of molar roots is a common variation of root morphology known to adversely affect periodontal disease prognosis. Among methods for inducing experimental periodontal disease in animal models, the ligature-induced periodontitis (LIP) mouse model is most frequently employed. However, few studies have examined root abnormalities in experimental mice. This study aimed to investigate the incidence of root fusion in the maxillary second molars of mice and determine its relationship with alveolar bone loss, offering new insights into animal LIP models.

Methods: From 2019 to February 2024, 222 Institute of Cancer Research mice (444 maxillary second molars), which served as control animals in periodontitis experiments conducted by the Department of Periodontology and the Department of Anatomy at the College of Dentistry, Gangneung-Wonju National University, were initially examined. After excluding fractured or missing teeth, 402 teeth were included in the final analysis. Root fusion was evaluated using micro-computed tomography and categorized by the degree of fusion. To examine the relationship between fused roots and alveolar bone loss, the distance from the cementoenamel junction to the alveolar bone crest was measured on the mesial and distal sides of the maxillary second molars.

Results: Root fusion was found in 10.4% of animals and 6.5% of teeth. Two types of fusion were observed: mesio-palatal (MP) and disto-palatal. Partial root fusion was more frequent than complete fusion. Within the ligation group, teeth with MP fusion exhibited greater alveolar bone loss than those without root fusion (P<0.05).

Conclusions: Within the limitations of this study, maxillary second molars with MP root fusion accelerated alveolar bone loss in ligated teeth in a LIP mouse model. Future research should consider deviations resulting from MP root fusion.

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来源期刊
Journal of Periodontal and Implant Science
Journal of Periodontal and Implant Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.30%
发文量
38
期刊介绍: Journal of Periodontal & Implant Science (JPIS) is a peer-reviewed and open-access journal providing up-to-date information relevant to professionalism of periodontology and dental implantology. JPIS is dedicated to global and extensive publication which includes evidence-based original articles, and fundamental reviews in order to cover a variety of interests in the field of periodontal as well as implant science.
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