{"title":"原位：用于靶向药物输送系统的微生物气动微针。","authors":"Chenyu Zong, Fei Wang, Wenguo Cui","doi":"10.34133/research.0775","DOIUrl":null,"url":null,"abstract":"<p><p><i>In situ</i> microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H<sub>2</sub>, NO, and H<sub>2</sub>S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H<sub>2</sub>S-mediated anti-inflammation) to modulate disease microenvironments. The system's biocompatibility (probiotic strains and <i>Lactobacillus</i>) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.</p>","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0775"},"PeriodicalIF":10.7000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342781/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>In Situ</i>: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems.\",\"authors\":\"Chenyu Zong, Fei Wang, Wenguo Cui\",\"doi\":\"10.34133/research.0775\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>In situ</i> microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H<sub>2</sub>, NO, and H<sub>2</sub>S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H<sub>2</sub>S-mediated anti-inflammation) to modulate disease microenvironments. The system's biocompatibility (probiotic strains and <i>Lactobacillus</i>) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.</p>\",\"PeriodicalId\":21120,\"journal\":{\"name\":\"Research\",\"volume\":\"8 \",\"pages\":\"0775\"},\"PeriodicalIF\":10.7000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342781/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.34133/research.0775\",\"RegionNum\":1,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Multidisciplinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.34133/research.0775","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Multidisciplinary","Score":null,"Total":0}
In Situ: Microbial Aerodynamic Microneedles for Targeted Drug Delivery Systems.
In situ microbial aerodynamic microneedles (MM-MNs) represent an autonomous transdermal drug delivery platform that utilizes the gas generated by microbial metabolism (e.g., H2, NO, and H2S) to propel drugs into deep tissues, surpassing the penetration limits of traditional microneedles reliant on external stimuli (heat/light/mechanical force). By leveraging controlled microbial metabolism, MM-MNs enable energy-independent, spatiotemporally precise delivery with enhanced targeting and bioavailability. Gas-driven propulsion combines with bioactive gas functions (e.g., NO-induced vasodilation and H2S-mediated anti-inflammation) to modulate disease microenvironments. The system's biocompatibility (probiotic strains and Lactobacillus) and scalability (cost-effective patch design) further support its potential for localized therapies (skin diseases and tumors) with minimized systemic exposure. This innovation bridges microbial biotechnology and precision medicine, offering a paradigm shift in transdermal delivery.
期刊介绍：
Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe.
Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.
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