澳大利亚婴儿2 + 1 DTPa启动计划的免疫原性和安全性以及母亲来源的抗体对4岁以下百日咳抗体反应的影响

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Journal of the Pediatric Infectious Diseases Society Pub Date : 2025-08-27 DOI:10.1093/jpids/piaf067

Sonia M McAlister, Alexandra Dierig, Anita H J van den Biggelaar, Ruth Thornton, Matthew N Cooper, Peter McIntyre, Peter C Richmond, Nicholas Wood

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引用次数: 0

摘要

我们评估了母源百日咳抗体对婴儿对2 + 1疫苗接种计划（6周、12周和12个月）反应的影响。具有基线抗体的婴儿在初次接种系列疫苗后显示出较低的IgG应答，但这并不影响4岁时的加强应答。该研究已在澳大利亚新西兰临床试验登记处注册- www.anzctr.org.au（第一部分：ACTRN12615000898550，第二部分：ACTRN12622001216707）。

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Immunogenicity and Safety of a 2 + 1 DTPa Priming Schedule in Australian Infants and the Impact of Maternally Derived Antibodies on Pertussis Antibody Responses up to 4 Years of Age.

We assessed the impact of maternally derived pertussis antibodies on infant responses to a 2 + 1 vaccine schedule (6 weeks, 12 weeks, and 12 months). Infants with baseline antibodies showed lower IgG responses following the primary vaccination series, but this did not impair booster responses at 4 years of age. Clinical Trials: The study is registered on the Australian New Zealand Clinical Trials Registry - www.anzctr.org.au (Part 1: ACTRN12615000898550, Part 2: ACTRN12622001216707).

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来源期刊

Journal of the Pediatric Infectious Diseases Society Medicine-Pediatrics, Perinatology and Child Health

CiteScore

6.70

自引率

0.00%

发文量

179

期刊介绍： The Journal of the Pediatric Infectious Diseases Society (JPIDS), the official journal of the Pediatric Infectious Diseases Society, is dedicated to perinatal, childhood, and adolescent infectious diseases. The journal is a high-quality source of original research articles, clinical trial reports, guidelines, and topical reviews, with particular attention to the interests and needs of the global pediatric infectious diseases communities.