生物活性吡啶类生物碱的化学合成与生物合成研究进展。

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Ning Chen, Xinyu Ma, Bing Liu, Ting Zhu, Yuchen Liu, Ting Li
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引用次数: 0

摘要

吡啶类生物碱具有重要的生物活性,广泛应用于医药、农药等领域。本文综述了吡啶类生物碱的化学合成和生物合成的研究进展。在化学合成方面,芳基吡啶类化合物的合成方法多种多样。例如,2,4,6-三芳基吡啶可以用铁有机骨架材料或其他试剂合成。具有芳基三唑结构的3-乙基砜吡啶类化合物可通过特定反应合成。2-芳基吡啶也可以用这种方法合成。杂环吡啶化合物可以通过多种方法制备成相应的衍生物。多取代吡啶的合成采用环加成、Diels-Alder、缩合、环化、芳构化等反应。聚吡啶的合成以新型配合物的构建为重点。介绍了超声辅助合成等其它合成方法。主要的生物合成途径包括聚酮合成酶与非核糖体肽合成酶的共合成、赖氨酸的起源、天冬氨酸的参与以及硫肽类抗生素的合成。同时,对功能性红曲米中吡啶素、吡啶色素化合物和维生素B6的生物合成途径进行了探讨,为吡啶类生物碱的进一步研究和应用提供了理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Pyridine Alkaloids.

Pyridine alkaloids possess important biological activities and are widely used in fields such as medicine and pesticides. This paper comprehensively reviews the research progress in the chemical synthesis and biosynthesis of pyridine alkaloids. In terms of chemical synthesis, there are diverse synthesis methods for arylpyridine compounds. For example, 2,4,6-triarylpyridine can be synthesized by using iron-organic framework materials or other reagents. The 3-ethylsulfone pyridine compounds with aryltriazole structures can be synthesized through specific reactions. And 2- arylpyridine can also be synthesized in this way. Heterocyclic pyridine compounds can be prepared into their corresponding derivatives through multiple approaches. The synthesis of polysubstituted pyridine adopts reactions such as cycloaddition, Diels-Alder, condensation, cyclization, and aromatization. The synthesis of polypyridine focuses on the construction of new complexes. Other synthesis methods such as ultrasound-assisted synthesis are also introduced. The main biosynthesis pathways include the co-synthesis of polyketide synthase and non-ribosomal peptide synthase, the origin of lysine, the participation of aspartate, and the synthesis of thiopeptide antibiotics. Meanwhile, the biosynthesis pathways of pyridomycin, pyridine pigment compounds in functional red yeast rice, and vitamin B6 were also discussed, which provides a theoretical basis for further research and application of pyridine alkaloids.

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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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