Ning Chen, Xinyu Ma, Bing Liu, Ting Zhu, Yuchen Liu, Ting Li
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Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Pyridine Alkaloids.
Pyridine alkaloids possess important biological activities and are widely used in fields such as medicine and pesticides. This paper comprehensively reviews the research progress in the chemical synthesis and biosynthesis of pyridine alkaloids. In terms of chemical synthesis, there are diverse synthesis methods for arylpyridine compounds. For example, 2,4,6-triarylpyridine can be synthesized by using iron-organic framework materials or other reagents. The 3-ethylsulfone pyridine compounds with aryltriazole structures can be synthesized through specific reactions. And 2- arylpyridine can also be synthesized in this way. Heterocyclic pyridine compounds can be prepared into their corresponding derivatives through multiple approaches. The synthesis of polysubstituted pyridine adopts reactions such as cycloaddition, Diels-Alder, condensation, cyclization, and aromatization. The synthesis of polypyridine focuses on the construction of new complexes. Other synthesis methods such as ultrasound-assisted synthesis are also introduced. The main biosynthesis pathways include the co-synthesis of polyketide synthase and non-ribosomal peptide synthase, the origin of lysine, the participation of aspartate, and the synthesis of thiopeptide antibiotics. Meanwhile, the biosynthesis pathways of pyridomycin, pyridine pigment compounds in functional red yeast rice, and vitamin B6 were also discussed, which provides a theoretical basis for further research and application of pyridine alkaloids.
期刊介绍:
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.