解读骨形态发生通路(BMP)在抑郁症发病机制中的潜力。

Q3 Medicine
Uma, Ravinder Verma, Pooja Mathur, Anju, Nisha Tiwetia, Ritu
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引用次数: 0

摘要

抑郁症是一种普遍存在的精神健康障碍,对个人产生深远影响,并经常因压力经历而加剧。目前的治疗方案有局限性,包括疗效降低和不良副作用。虽然抗抑郁药物针对不同的大脑区域,但其影响行为的确切机制仍未完全阐明。最近的研究强调了海马体内骨形态发生蛋白(BMP)信号通路在调节各种抗抑郁药物作用中的重要性。值得注意的是,这些药物抑制BMP信号,从而增加海马体的神经发生。在新生成的脑细胞中特异性地抑制BMP信号会产生抗抑郁作用,而抑制这些细胞则会阻碍这种结果。这强调了BMP信号在抗抑郁作用机制中的关键作用。成人神经发生,特别是海马体中的神经发生,在情绪调节和应激反应中起着关键作用。压力会减少新脑细胞的生成,而长期服用抗抑郁药则会促进神经生成,这表明神经生成与抑郁之间存在联系。研究抑郁、焦虑和抗抑郁药物疗效的分子和细胞机制,有望开发出以快速缓解和减少副作用为特征的改进治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deciphering the Potential of Bone Morphogenetic Pathway (BMP) in the Pathogenesis Of Depression.

Depression is a prevalent mental health disorder, profoundly impacting individuals and often exacerbated by stressful experiences. Current treatment options have limitations, including reduced efficacy and undesirable side effects. While antidepressant medications target distinct brain regions, their precise mechanisms influencing behavior remain incompletely elucidated. Recent research underscores the significance of the bone morphogenetic protein (BMP) signaling pathway within the hippocampus in mediating the effects of various antidepressants. Notably, these drugs inhibit BMP signaling, thereby augmenting neurogenesis in the hippocampus. Inhibiting BMP signaling specifically in newly generated brain cells elicits antidepressant effects, whereas suppressing these cells impedes such outcomes. This underscores the pivotal role of BMP signaling in the mechanism of antidepressant action. Adult neurogenesis, particularly in the hippocampus, emerges as pivotal for emotional regulation and stress response. Stress reduces the generation of new brain cells, whereas prolonged use of antidepressants promotes neurogenesis, suggesting a link between neurogenesis and depression. Investigating the molecular and cellular mechanisms underlying depression, anxiety, and antidepressant efficacy holds promise for the development of improved treatments characterized by rapid relief and reduced side effects.

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来源期刊
Current aging science
Current aging science Medicine-Geriatrics and Gerontology
CiteScore
3.90
自引率
0.00%
发文量
40
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