从基础生物学到毒理学的一次意外。

IF 13.1 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Ana M Soto
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引用次数: 0

摘要

当我年轻的时候,我想象着我的未来,它不是一条可以先验地确定的道路。这个世界充满了有趣的事情。获得成为教授和研究员的资格是容易的部分。其余的依靠的是在正确的时间出现在正确的地点,并有直觉感受到我们所目睹的事件的重要性。这就是我如何遇到我的导师,以及我和我的科学伙伴如何遇到导致我们提出生物惯性原理的悖论。这也是我们如何发现从塑料器皿中浸出的雌激素破坏了我们的实验,因此我们偶然成为了“毒理学家”。事实上,我们从未接受过药理学或毒理学的正式培训;然而,我们发现从塑料中浸出的雌激素壬基酚使我们成为包括内分泌学和毒理学在内的内分泌干扰物新领域的先驱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From Fundamental Biology to Toxicology by Way of an Accident.

When I was young and pictured my future, it wasn't a path that could be determined a priori. The world was full of interesting things. Obtaining the qualifications to become a professor and a researcher was the easy part. The rest relied on being in the right place at the right moment and having the intuition to feel the importance of events we were witnessing. This is how I met my mentors and how my scientific partner and I came upon the paradox that caused us to propose the principle of biological inertia. This is also how we discovered that estrogens leached from plasticware were ruining our experiments, and thus we became "toxicologists by accident." Indeed, we were never formally trained in pharmacology or toxicology; however, our discovery that the estrogen nonylphenol leached from plastics made us pioneers of the new field of endocrine disruptors that encompasses endocrinology and toxicology.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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