Pd（II）催化3-甲酰基吲哚与硝基烯脱羧-烷基化反应得到3-（2-硝基烷基）吲哚

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-08-14 DOI:10.1002/slct.202504368

Xiaoge Wang, Xiaoqian Liu, Guangming Yue, Yongmei Wu, Ru Zhao, Shuang-Liang Liu

引用次数: 0

摘要

本文报道了Pd（II）催化的3-甲酰基吲哚与硝基烯氧化脱羧反应，得到了各种3-（2-硝基烷基）吲哚，这些吲哚可用于制备色胺类及相关含吲哚的生物活性化合物。该反应具有底物范围广、区域选择性高的特点。为了深入了解反应机理，进行了机理研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pd(II)-Catalyzed Decarboxylation-Alkylation of 3-Formylindoles with Nitroalkenes to Access 3-(2-Nitroalkyl)indoles

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Pd(II)-Catalyzed Decarboxylation-Alkylation of 3-Formylindoles with Nitroalkenes to Access 3-(2-Nitroalkyl)indoles

We present herein a Pd(II)-catalyzed oxidative decarboxylation reaction of 3-formylindoles with nitroalkenes to construct various 3-(2-nitroalkyl)indoles, which can be used to prepare tryptamines and related indole-containing bioactive compounds. The reaction features broad substrate scope and high regioselectivity. Mechanistic studies were carried out to shed insights into the reaction mechanism.

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.