利用可激活Janus纳米探针进行NIR-II成像和酶样活性监测肝纤维化

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Zhouyu Yu, Lijia Zou, Ruiqi Liu, Xiaoyan Zhang, Zhen Cheng, Si Chen, Baisong Chang
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引用次数: 0

摘要

由于肝纤维化可能发展为肝硬化、肝功能衰竭或肝细胞癌,因此肝纤维化是一个重大的全球健康挑战,这突出了对纤维化进展进行精确成像的必要性。本文提出了一种直接的合成方法来设计能够实现肝纤维化高分辨率生物成像的生物反应纳米探针。经聚乙二醇修饰的Janus MnO2包覆Ag/Ag2S纳米粒子(jMAP)在病理微环境中可以继承Ag/Ag2S和MnO2组分的可活化特性。多项证据表明,肝纤维化中活性氧(ROS)的过表达水平有效地将jMAP纳米探针转化为Ag2S产物,在第二个近红外窗口(NIR-II, 1000-1700 nm)激活明亮荧光。此外,jMAP探针具有过氧化氢酶样和超氧化物歧化酶样活性,对ROS的清除率约为73.3%,可减少缺氧和氧化应激,从而使缺氧诱导因子(HIF-1α)和NADPH氧化酶-4 (NOX-4)分别下调49.5%和47.9%。总的来说,开发的jMAP探针显示出令人印象深刻的诊断准确性,为肝纤维化诊断提供了变革性的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis

Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis

Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis

Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis

Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis

Liver fibrosis presents a significant global health challenge due to its potential progression to cirrhosis, liver failure, or hepatocellular carcinoma, highlighting the necessity for precise imaging of fibrosis progression. Here, a straightforward synthesis method is proposed to design bioresponsive nanoprobes capable of achieving high-resolution bioimaging of liver fibrosis. Janus MnO2-coated Ag/Ag2S nanoparticles modified by polyethylene glycol (denoted as jMAP) can inherit both the activatable properties from Ag/Ag2S and MnO2 components in the pathological microenvironment. Multiple lines of evidence supported that overexpressed levels of reactive oxygen species (ROS) in liver fibrosis efficiently transformed jMAP nanoprobes to Ag2S products, activating bright fluorescence in the second near-infrared window (NIR-II, 1000–1700 nm). In addition, the catalase-like and superoxide dismutase-like activities of jMAP probes reduce hypoxia and oxidative stress with a clearance rate of about 73.3% toward ROS, thereby downregulating hypoxia-inducible factor (HIF-1α) and NADPH oxidase-4 (NOX-4) by 49.5% and 47.9%, respectively. Overall, the developed jMAP probes demonstrate impressive diagnostic accuracy, offering transformative prospects for liver fibrosis diagnosis.

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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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