革新精准医学:揭示智能刺激反应纳米医学

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Ayushi Taneja, Himanshu Sekhar Panda, Jiban Jyoti Panda, Thakur Gurjeet Singh, Avneet Kour
{"title":"革新精准医学:揭示智能刺激反应纳米医学","authors":"Ayushi Taneja,&nbsp;Himanshu Sekhar Panda,&nbsp;Jiban Jyoti Panda,&nbsp;Thakur Gurjeet Singh,&nbsp;Avneet Kour","doi":"10.1002/adtp.202500073","DOIUrl":null,"url":null,"abstract":"<p>Smart stimuli-responsive nanomaterials have emerged as promising candidates in pharmaceutical delivery due to their ability to react to diverse physical, chemical, and biological stimuli. These systems can be precisely engineered to release therapeutic agents in response to specific internal cues, allowing for controlled and targeted interventions tailored to individual patient conditions. Their nanoscale architecture, ease of surface modification, and multifunctional physicochemical properties further enhance their suitability for biomedical applications. Recent advances underscore their potential in treating complex and chronic diseases such as cancer, neurological disorders, and inflammatory conditions, where conventional therapies often fall short. By integrating these responsive nanotechnologies into precision medicine, it is possible to enhance therapeutic efficacy while minimizing systemic toxicity. Herein, this work highlights the ongoing progress in the development and application of stimuli-responsive nanomedicines. This work also emphasizes the need for extensive clinical validation to determine their long-term safety and effectiveness in human subjects.</p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 8","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Revolutionizing Precision Medicine: Unveiling Smart Stimuli-Responsive Nanomedicine\",\"authors\":\"Ayushi Taneja,&nbsp;Himanshu Sekhar Panda,&nbsp;Jiban Jyoti Panda,&nbsp;Thakur Gurjeet Singh,&nbsp;Avneet Kour\",\"doi\":\"10.1002/adtp.202500073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Smart stimuli-responsive nanomaterials have emerged as promising candidates in pharmaceutical delivery due to their ability to react to diverse physical, chemical, and biological stimuli. These systems can be precisely engineered to release therapeutic agents in response to specific internal cues, allowing for controlled and targeted interventions tailored to individual patient conditions. Their nanoscale architecture, ease of surface modification, and multifunctional physicochemical properties further enhance their suitability for biomedical applications. Recent advances underscore their potential in treating complex and chronic diseases such as cancer, neurological disorders, and inflammatory conditions, where conventional therapies often fall short. By integrating these responsive nanotechnologies into precision medicine, it is possible to enhance therapeutic efficacy while minimizing systemic toxicity. Herein, this work highlights the ongoing progress in the development and application of stimuli-responsive nanomedicines. This work also emphasizes the need for extensive clinical validation to determine their long-term safety and effectiveness in human subjects.</p>\",\"PeriodicalId\":7284,\"journal\":{\"name\":\"Advanced Therapeutics\",\"volume\":\"8 8\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Therapeutics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adtp.202500073\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adtp.202500073","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

智能刺激响应纳米材料由于其对各种物理、化学和生物刺激的反应能力,已成为药物输送中有前途的候选者。这些系统可以精确设计,根据特定的内部信号释放治疗剂,允许针对个体患者的情况进行控制和有针对性的干预。它们的纳米级结构、易于表面修饰和多功能物理化学性质进一步增强了它们在生物医学应用中的适用性。最近的进展强调了它们在治疗复杂和慢性疾病(如癌症、神经系统疾病和炎症)方面的潜力,而传统疗法往往在这些方面达不到要求。通过将这些反应性纳米技术整合到精准医学中,有可能提高治疗效果,同时最大限度地减少全身毒性。在此,本工作强调了刺激反应性纳米药物的开发和应用的持续进展。这项工作还强调需要广泛的临床验证,以确定它们在人类受试者中的长期安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Revolutionizing Precision Medicine: Unveiling Smart Stimuli-Responsive Nanomedicine

Revolutionizing Precision Medicine: Unveiling Smart Stimuli-Responsive Nanomedicine

Revolutionizing Precision Medicine: Unveiling Smart Stimuli-Responsive Nanomedicine

Revolutionizing Precision Medicine: Unveiling Smart Stimuli-Responsive Nanomedicine

Revolutionizing Precision Medicine: Unveiling Smart Stimuli-Responsive Nanomedicine

Smart stimuli-responsive nanomaterials have emerged as promising candidates in pharmaceutical delivery due to their ability to react to diverse physical, chemical, and biological stimuli. These systems can be precisely engineered to release therapeutic agents in response to specific internal cues, allowing for controlled and targeted interventions tailored to individual patient conditions. Their nanoscale architecture, ease of surface modification, and multifunctional physicochemical properties further enhance their suitability for biomedical applications. Recent advances underscore their potential in treating complex and chronic diseases such as cancer, neurological disorders, and inflammatory conditions, where conventional therapies often fall short. By integrating these responsive nanotechnologies into precision medicine, it is possible to enhance therapeutic efficacy while minimizing systemic toxicity. Herein, this work highlights the ongoing progress in the development and application of stimuli-responsive nanomedicines. This work also emphasizes the need for extensive clinical validation to determine their long-term safety and effectiveness in human subjects.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信