碱介导[4 + 2]环化法制备3,3-二取代四氢异喹啉类化合物

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-17 DOI:10.1002/ajoc.202500563

Jiaxu Feng, Yingying Wu, Lulu Xu, Xiangdi Wang

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引用次数: 0

摘要

在这项研究中，我们提出了一种在温和条件下通过α-氨基酸酯衍生物和1,2-双（溴乙基）苯的碱基介导[4 + 2]环化制备3,3-二取代thiq的简单而优雅的方法。该工艺具有良好的底物耐受性，温和的条件和中等至优异的产量。扩大规模的实验和进一步的结构阐述突出了该议定书的综合潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of 3,3-disubstituted Tetrahydroisoquinolines (THIQs) via Base-mediated [4 + 2] Annulation

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Synthesis of 3,3-disubstituted Tetrahydroisoquinolines (THIQs) via Base-mediated [4 + 2] Annulation

In this research we represented a simple and elegant method for 3,3-disubstituted THIQs via base-mediated [4 + 2] annulation of α-amino acid ester derivatives and 1,2-bis(bromomethyl)benzene under mild conditions. This protocol features good substrate tolerance, mild conditions and moderate to excellent yields. The synthetic potential of this protocol was highlighted by scale-up experiments and further structural elaboration.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.