Emily K. Schworer, Matthew D. Zammit, Benjamin L. Handen, Brianna Piro-Gambetti, Melissa R. Jenkins, Courtney Brothers, Ozioma C. Okonkwo, Christy L. Hom, Beau M. Ances, Bradley T. Christian, Sigan L. Hartley
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Lifestyle composites were created by assessing time spent in leisure, employment, and physical activity across 7 days through informant reports and accelerometry.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>There was a significant moderation effect of the lifestyle composite on the association between amyloid age and the NTG-EDSD and DSMSE. Participants with a higher lifestyle composite (higher leisure, employment engagement, and physical activity) had fewer dementia symptoms than those with a lower lifestyle composite score of a similar amyloid age.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Modifiable lifestyle factors may allow adults with DS to maintain cognitive functioning for longer in the face of AD pathology.</p>\n </section>\n </div>","PeriodicalId":51403,"journal":{"name":"Journal of Applied Research in Intellectual Disabilities","volume":"38 4","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jar.70109","citationCount":"0","resultStr":"{\"title\":\"Lifestyle Composite and Resilience to Alzheimer's Disease Pathology in Down Syndrome\",\"authors\":\"Emily K. Schworer, Matthew D. Zammit, Benjamin L. 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Lifestyle Composite and Resilience to Alzheimer's Disease Pathology in Down Syndrome
Background
People with Down syndrome (DS) have a high risk for Alzheimer's disease (AD). Identifying resiliency factors for AD is of critical importance to the DS community.
Method
Participants were 63 adults with DS. Measures included amyloid-beta PET scans (amyloid age), National Task Group-Early Detection Screen for Dementia (NTG-EDSD), and Down Syndrome Mental Status Examination (DSMSE). Lifestyle composites were created by assessing time spent in leisure, employment, and physical activity across 7 days through informant reports and accelerometry.
Results
There was a significant moderation effect of the lifestyle composite on the association between amyloid age and the NTG-EDSD and DSMSE. Participants with a higher lifestyle composite (higher leisure, employment engagement, and physical activity) had fewer dementia symptoms than those with a lower lifestyle composite score of a similar amyloid age.
Conclusions
Modifiable lifestyle factors may allow adults with DS to maintain cognitive functioning for longer in the face of AD pathology.
期刊介绍：
JARID is an international, peer-reviewed journal which draws together findings derived from original applied research in intellectual disabilities. The journal is an important forum for the dissemination of ideas to promote valued lifestyles for people with intellectual disabilities. It reports on research from the UK and overseas by authors from all relevant professional disciplines. It is aimed at an international, multi-disciplinary readership. Topics covered include community living, quality of life, challenging behaviour, communication, sexuality, medication, ageing, supported employment, family issues, mental health, physical health, autism, economic issues, social networks, staff stress, staff training, epidemiology and service provision.
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