2型糖尿病患者血清维生素D与蛋白尿的关系,与炎症标志物和肾功能无关

IF 2.6 Q3 ENDOCRINOLOGY & METABOLISM
Parisa Farshchi, Sahar Karimpour Reyhan, Mahsa Abbaszadeh, Soghra Rabizadeh, Alireza Esteghamati, Nasim Khajavi Rad, Soheil Karimpour Reyhan, Elahe Saffari, Manouchehr Nakhjavani
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引用次数: 0

摘要

前言探讨2型糖尿病(T2D)患者血清高敏c反应蛋白(hs-CRP)、组织坏死因子-α (TNF-α)、25-羟基维生素D (25(OH)维生素D)与蛋白尿的关系。方法对86例t2dm患者进行横断面研究,根据尿白蛋白与肌酐比值(UACR)分为有蛋白尿和无蛋白尿两组。25(OH)维生素D浓度≤15 ng/mL为维生素D缺乏,15 ~ 30 ng/mL为维生素D不足,30 ng/mL为血清25(OH)维生素D充足。hs-CRP水平≤2.5 mg/L为低水平,而hs-CRP水平≤2.5 mg/L为高水平。根据受试者工作特征(ROC)曲线分析将TNF-α分为高、低两类,临界值为8.2 pg/mL。P值<; 0.05被认为与蛋白尿显著相关。结果合并蛋白尿的t2dm患者维生素D缺乏明显多于无蛋白尿的t2dm患者(调整后OR = 7.34, 95% CI = 2.3 ~ 23.6, p = 0.001)。较高的血清TNF-α水平(TNF-α > 8.2 pg/mL)与T2D患者蛋白尿的存在更频繁地相关(调整OR = 6.77, 95% CI = 1.61-28.4;p = 0.009)。同样,血清hs-CRP水平升高(hs-CRP > 2.5 mg/L)在有T2D和蛋白尿的患者中比没有T2D和蛋白尿的患者更常见(调整后OR = 4.7, 95% CI = 1.4-15.8;p = 0.012)。结论维生素D缺乏与T2D患者蛋白尿有显著相关性,与肾小球滤过率(GFR)和hs-CRP、TNF-α等基本炎症标志物无关。血清hs-CRP >; 2.5 mg/L、TNF-α >;8.2 pg/mL分别与T2D患者蛋白尿的可能性显著增加相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association Between Serum Vitamin D and Albuminuria in Type 2 Diabetes Independent of Inflammatory Markers and Renal Function

Association Between Serum Vitamin D and Albuminuria in Type 2 Diabetes Independent of Inflammatory Markers and Renal Function

Introduction

To explore the relationship between serum high-sensitivity C-reactive protein (hs-CRP), tissue necrosis factor-α (TNF-α) and 25-Hydroxyvitamin D (25(OH) vitamin D) with albuminuria in patients with type 2 diabetes mellitus (T2D).

Methods

This was a cross-sectional study of 86 T2D patients divided into categories of with and without albuminuria based on the urine albumin-to-creatinine ratio (UACR). A 25(OH) vitamin D concentration ≤ 15 ng/mL was defined as vitamin D deficiency, within 15–30 ng/mL as vitamin D insufficiency, and > 30 ng/mL as serum 25(OH) vitamin D sufficiency. A hs-CRP level ≤ 2.5 mg/L was considered low, whereas a hs-CRP level > 2.5 mg/L was considered high. TNF-α was classified as low or high with an 8.2 pg/mL cutoff level based on receiver operating characteristic (ROC) curve analysis. P values < 0.05 were considered to be significantly associated with albuminuria.

Results

Vitamin D deficiency was significantly more commonly observed among T2D patients with albuminuria than those without albuminuria (adjusted OR = 7.34, 95% CI = 2.3–23.6, p = 0.001). Higher serum TNF-α levels (TNF-α > 8.2 pg/mL) were more frequently associated with the presence of albuminuria in T2D patients (adjusted OR = 6.77, 95% CI = 1.61–28.4; p = 0.009). Similarly, elevated serum hs-CRP levels (hs-CRP > 2.5 mg/L) were more commonly found among patients with T2D and albuminuria than in those without (adjusted OR = 4.7, 95% CI = 1.4–15.8; p = 0.012).

Conclusions

Vitamin D deficiency is a significant correlate of albuminuria in T2D patients, independent of glomerular filtration rate (GFR) and basic inflammatory markers including hs-CRP and TNF-α. Moreover, serum hs-CRP > 2.5 mg/L and TNF-α > 8.2 pg/mL were each individually associated with a significantly increased likelihood of albuminuria in T2D patients.

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来源期刊
Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.00
自引率
0.00%
发文量
66
审稿时长
6 weeks
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