对甲苯磺酰肼与n -杂芳酮的可切换反应：n -杂芳醇和[1,2,3]-三唑杂芳烯的碱控制选择性合成

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-06-16 DOI:10.1002/ajoc.202500408

Yifei Wu, Rurong Yu, Feiyue Hao, Zhengneng Jin, Jiashou Wu

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引用次数: 0

摘要

建立了对甲苯磺酰肼与n -杂芳酮的可转换反应，合成n -杂芳醇和[1,2,3]-三唑杂芳烯。对甲苯磺酰肼在Et3N存在下是n -杂芳基酮的有效还原剂。当氢氧化钠作为碱时，发生了级联环化反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Switchable Reaction of p-Toluenesulfonyl Hydrazide With N-Heteroaryl Ketones: Base-Controlled Selective Synthesis of N-Heteroaryl Alcohols and [1, 2, 3]-Triazoloheteroarenes

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Switchable Reaction of p-Toluenesulfonyl Hydrazide With N-Heteroaryl Ketones: Base-Controlled Selective Synthesis of N-Heteroaryl Alcohols and [1, 2, 3]-Triazoloheteroarenes

A novel switchable reaction of p-toluenesulfonyl hydrazide with N-heteroaryl ketones has been developed to synthesize N-heteroaryl alcohols and [1, 2, 3]-triazoloheteroarenes. p-Toluenesulfonyl hydrazide was found to be an efficient reducing agent for N-heteroaryl ketones in the presence of Et₃N. A cascade cyclization reaction occurred when NaOH was applied as a base.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.