{"title":"肺功能与阿尔茨海默病发生风险的关联：一项前瞻性队列和孟德尔随机化研究","authors":"Ya-Nan Zheng, Peng Qiu, Hui-Huan Luo, Ren-Jie Chen, Xue-Qiang Wang, Pei-Jie Chen","doi":"10.1007/s40520-025-03151-z","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>The causal association between pulmonary function and Alzheimer’s disease (AD) remains unclear. This study aimed to investigate whether low pulmonary function has a causal relationship with the risk of AD.</p><h3>Methods</h3><p>We conducted prospective cohort and two-sample Mendelian randomization (MR) studies. In the cohort study, 333,816 UK Biobank participants were eligible for analysis. Forced expiratory volume in the first second (FEV<sub>1</sub>), forced vital capacity (FVC), FEV<sub>1</sub>/FVC ratio, percentage of predicted normal value of FEV<sub>1</sub> (FEV<sub>1</sub>% pred), and peak expiratory flow (PEF) were measured at baseline. Longitudinal associations were investigated using cox-proportional hazard models. We conducted univariate and multivariable MR analyses on genome-wide association study (GWAS) data from 421,986 Europeans for FEV<sub>1</sub>, FVC, and PEF. Inverse-variance weighting was employed as the primary MR analysis approach.</p><h3>Results</h3><p>Over a median follow-up of 12.8 years (10.3–15.0 years), 2275 incident cases of AD were identified in the cohort study. Compared to the highest quartile, the lowest quartile for pulmonary function exhibited a higher risk of incident AD, and hazard ratios (95% CI) were as follows after adjustment for risk factors: 1.81 (1.32–2.48; FEV<sub>1</sub>), 1.97 (1.44–2.69; FVC), and 1.86 (1.39–2.47; PEF). In the MR study, genetically determined high FEV<sub>1</sub> was associated with a decreased risk of AD (odds ratio: 0.68, 95% CI: 0.53–0.88). The results remained robust after sensitivity and multivariable MR analyses.</p><h3>Conclusion</h3><p>Our findings suggest the potential causal association between high FEV<sub>1</sub> and decreased risk of AD.</p></div>","PeriodicalId":7720,"journal":{"name":"Aging Clinical and Experimental Research","volume":"37 1","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40520-025-03151-z.pdf","citationCount":"0","resultStr":"{\"title\":\"Association of pulmonary function with the risk of incident Alzheimer’s disease: a prospective cohort and Mendelian randomization study\",\"authors\":\"Ya-Nan Zheng, Peng Qiu, Hui-Huan Luo, Ren-Jie Chen, Xue-Qiang Wang, Pei-Jie Chen\",\"doi\":\"10.1007/s40520-025-03151-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>The causal association between pulmonary function and Alzheimer’s disease (AD) remains unclear. This study aimed to investigate whether low pulmonary function has a causal relationship with the risk of AD.</p><h3>Methods</h3><p>We conducted prospective cohort and two-sample Mendelian randomization (MR) studies. In the cohort study, 333,816 UK Biobank participants were eligible for analysis. Forced expiratory volume in the first second (FEV<sub>1</sub>), forced vital capacity (FVC), FEV<sub>1</sub>/FVC ratio, percentage of predicted normal value of FEV<sub>1</sub> (FEV<sub>1</sub>% pred), and peak expiratory flow (PEF) were measured at baseline. Longitudinal associations were investigated using cox-proportional hazard models. We conducted univariate and multivariable MR analyses on genome-wide association study (GWAS) data from 421,986 Europeans for FEV<sub>1</sub>, FVC, and PEF. Inverse-variance weighting was employed as the primary MR analysis approach.</p><h3>Results</h3><p>Over a median follow-up of 12.8 years (10.3–15.0 years), 2275 incident cases of AD were identified in the cohort study. Compared to the highest quartile, the lowest quartile for pulmonary function exhibited a higher risk of incident AD, and hazard ratios (95% CI) were as follows after adjustment for risk factors: 1.81 (1.32–2.48; FEV<sub>1</sub>), 1.97 (1.44–2.69; FVC), and 1.86 (1.39–2.47; PEF). In the MR study, genetically determined high FEV<sub>1</sub> was associated with a decreased risk of AD (odds ratio: 0.68, 95% CI: 0.53–0.88). The results remained robust after sensitivity and multivariable MR analyses.</p><h3>Conclusion</h3><p>Our findings suggest the potential causal association between high FEV<sub>1</sub> and decreased risk of AD.</p></div>\",\"PeriodicalId\":7720,\"journal\":{\"name\":\"Aging Clinical and Experimental Research\",\"volume\":\"37 1\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s40520-025-03151-z.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging Clinical and Experimental Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40520-025-03151-z\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging Clinical and Experimental Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s40520-025-03151-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Association of pulmonary function with the risk of incident Alzheimer’s disease: a prospective cohort and Mendelian randomization study
Introduction
The causal association between pulmonary function and Alzheimer’s disease (AD) remains unclear. This study aimed to investigate whether low pulmonary function has a causal relationship with the risk of AD.
Methods
We conducted prospective cohort and two-sample Mendelian randomization (MR) studies. In the cohort study, 333,816 UK Biobank participants were eligible for analysis. Forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, percentage of predicted normal value of FEV1 (FEV1% pred), and peak expiratory flow (PEF) were measured at baseline. Longitudinal associations were investigated using cox-proportional hazard models. We conducted univariate and multivariable MR analyses on genome-wide association study (GWAS) data from 421,986 Europeans for FEV1, FVC, and PEF. Inverse-variance weighting was employed as the primary MR analysis approach.
Results
Over a median follow-up of 12.8 years (10.3–15.0 years), 2275 incident cases of AD were identified in the cohort study. Compared to the highest quartile, the lowest quartile for pulmonary function exhibited a higher risk of incident AD, and hazard ratios (95% CI) were as follows after adjustment for risk factors: 1.81 (1.32–2.48; FEV1), 1.97 (1.44–2.69; FVC), and 1.86 (1.39–2.47; PEF). In the MR study, genetically determined high FEV1 was associated with a decreased risk of AD (odds ratio: 0.68, 95% CI: 0.53–0.88). The results remained robust after sensitivity and multivariable MR analyses.
Conclusion
Our findings suggest the potential causal association between high FEV1 and decreased risk of AD.
期刊介绍：
Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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