用于检测和诊断假体周围关节感染的微流控和芯片实验室设备

IF 3.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Biomedical Microdevices Pub Date : 2025-08-14 DOI:10.1007/s10544-025-00768-9

Luca Pellegrino, Alberto Bulgarelli, Cristina Belgiovine, Mattia Loppini, Roberto Rusconi

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引用次数: 0

摘要

假体周围关节感染（PJI）是人工关节植入的严重并发症，给个人和社会都带来了沉重的负担。有效的治疗依赖于迅速查明根本原因；然而，PJI的诊断仍然具有挑战性，效率低下且耗时。目前基于临床体征和常规培养的检测方案往往不能提供明确的结果。此外，滑液样本的先进分子分析虽然有效，但需要专业人员，并且不适合现场应用。本文综述了微流控技术和芯片实验室技术在提高PJI的识别能力、提供快速准确的诊断方法方面的潜力。

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Microfluidic and lab-on-a-chip devices for detection and diagnosis of periprosthetic joint infections

Periprosthetic joint infection (PJI) is a serious complication of prosthetic joint implantation, which poses a significant burden on both individuals and society. Effective treatment relies on the rapid identification of the underlying cause; however, the diagnosis of PJI remains challenging, inefficient, and time-consuming. Current detection protocols based on clinical signs and conventional cultures often fail to provide definitive results. Additionally, advanced molecular analyses of synovial fluid samples, while effective, require specialized personnel and are impractical for on-site applications. This review aims to highlight the potential of microfluidic and lab-on-a-chip technologies in enhancing the identification of PJI, offering a rapid and accurate diagnostic method.

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.