老年性黄斑变性眼网状假性视网膜面积的纵向评价

IF 4.6 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2025-07-07 DOI:10.1016/j.xops.2025.100881

Swetha Bindu Velaga MS , Ahmed Roshdy Alagorie MD , Muneeswar Gupta Nittala MPhil , Noel C. Moore PhD , Yeunjoo E. Song PhD , Jonathan Haines PhD , Margaret A. Pericak-Vance PhD , Dwight Stambolian MD , Zhihong Hu PhD , Ye He MD, PhD , Srinivas R. Sadda MD

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引用次数: 0

摘要

目的探讨老年性黄斑变性（AMD）患者2年内网状假性黄斑（RPD）面积及脉络膜厚度的变化。设计纵向队列研究。该研究回顾了来自666名受试者的1332只眼睛的基线和2年随访数据，其中108只眼睛被分级为RPD。其中，22名参与者35只眼睛(平均年龄：72.8±8.9岁；范围:50 - 84;37%的女性)有资格进行这项分析，因为他们在基线时患有早期或中期AMD并RPD， 2年后没有地理萎缩，并且图像可分级是否存在RPD。方法对所有受试者进行基线和2年时的红外反射率（IR）、蓝光眼底自身荧光和光谱域OCT检测。使用仪器软件，一个经过认证的分级员使用徒手工具在红外图像上划定RPD区域（mm2）。使用先前描述的深度学习算法来计算脉络膜体积，测量基线和第24个月的脉络膜厚度。主要观察指标：基线和2年间RPD面积（mm2）和平均脉络膜厚度（μm）的变化。结果RPD面积明显增大(P <；0.001)，与基线相比，第24个月平均增加6.23±4.64 mm2。平均脉络膜体积厚度从基线182.2±94.36（134.20-227.90）到24月178.2±41.10（109-258）无显著差异。在这项纵向自然史分析中，我们观察到在脉络膜厚度没有明显变化的情况下，RPD面积在2年内增加了6mm2。虽然伴有RPD的AMD眼睛通常有较薄的脉络膜，但这些病变范围的增加似乎与脉络膜的进一步变薄无关。财务披露专有或商业披露可在本文末尾的脚注和披露中找到。

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Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration

Purpose

To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD).

Design

Longitudinal cohort study.

Subjects

The study reviewed 1332 eyes from 666 subjects with baseline and 2-year follow-up data, of which 108 eyes were graded to have RPD. Among these, 35 eyes from 22 participants (mean age: 72.8 ± 8.9 years; range: 50–84; 37% female) were eligible for this analysis because they had early or intermediate AMD with RPD at baseline, absence of geographic atrophy at 2 years, and images that were gradable for the presence of RPD.

Methods

Infrared reflectance (IR), blue-light fundus autofluorescence, and spectral-domain OCT were obtained for all subjects at baseline and at 2 years. Using the instrument software, a certified grader delineated the RPD area (mm²) on the IR image using the free hand tool. Choroidal thickness was measured for both baseline and month 24 using a previously described deep learning algorithm to compute a choroidal volume.

Main Outcome Measures

Changes in RPD area (mm²) and mean volumetric choroidal thickness (μm) between baseline and 2 years.

Results

The RPD area increased significantly (P < 0.001) by month 24 compared with baseline with a mean increase of 6.23 ± 4.64 mm². The mean volumetric choroidal thickness was not significantly different from baseline 182.2 ± 94.36 (134.20–227.90) to month 24 178.2 ± 41.10 (109–258).

Conclusions

In this longitudinal natural history analysis, we observed an increase in RPD area of >6 mm² over 2 years in the absence of a significant change in choroidal thickness. Although AMD eyes with presence of RPD typically have a thinner choroid, the increase in extent of these lesions does not appear to be associated with further thinning of the choroid.