COVID-19感染后新发糖尿病：系统综述和荟萃分析

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-08-11 DOI:10.1016/j.diabres.2025.112417

Emma Cocking , Joseph Daher , Majid Alabbood

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引用次数: 0

摘要

本系统综述和荟萃分析旨在确定COVID-19患者与未患COVID-19患者相比新发糖尿病（NODM）的相对风险，并根据糖尿病类型、年龄、COVID-19感染严重程度和皮质类固醇使用情况进行亚组分析。方法系统检索spubmed、Medline、Embase和Scopus，检索同行评议的队列研究，比较COVID-19患者与非COVID-19对照组NODM的发病率。进行随机效应荟萃分析以确定COVID-19感染后NODM的相对风险。结果共纳入12项研究，涉及4800多万名参与者。与对照组相比，COVID-19感染后患者发生NODM的风险高41% (RR 1.41；95% ci 1.07-1.84)。亚组分析显示，与1型糖尿病相比，COVID-19感染后2型糖尿病的发病率更高，成人和疾病严重程度较高的患者发生NODM的风险增加。结论covid -19感染与NODM发生风险显著增高相关。COVID-19感染后应考虑密切监测高血糖，特别是需要住院或ICU住院的成年患者。

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New-onset diabetes mellitus post COVID-19 infection: a systematic review and meta-analysis

Aims

This systematic review and meta-analysis aimed to determine the relative risk of new-onset diabetes mellitus (NODM) in COVID-19 patients compared to individuals without COVID-19, with subgroup analyses based on diabetes type, age, severity of COVID-19 infection and corticosteroid use.

Methods

PubMed, Medline, Embase, and Scopus were systematically searched for peer-reviewed cohort studies comparing NODM incidence in COVID-19 patients against a control group without COVID-19. A random-effects meta-analysis was conducted to determine the relative risk of NODM following COVID-19 infection.

Results

A total of 12 studies were included, involving over 48 million participants. The risk of developing NODM was 41 % higher in patients following COVID-19 infection compared to the control group (RR 1.41; 95 % CI 1.07–1.84). Subgroup analysis revealed a higher incidence of type 2 compared to type 1 diabetes mellitus post COVID-19 infection, and increased risk of NODM in adults and patients with higher severity of disease.

Conclusion

COVID-19 infection is associated with a significantly higher risk of NODM. Close monitoring for hyperglycaemia should be considered following COVID-19 infection, especially in adult patients requiring hospital or ICU admission.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.