年轻发病结直肠癌的全球视角：流行病学、挑战和进展

IF 0.5 Q4 SURGERY

Seminars in Colon and Rectal Surgery Pub Date : 2025-07-22 DOI:10.1016/j.scrs.2025.101118

Drew Goldberg , Erica Pettke

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引用次数: 0

摘要

结直肠癌（CRC）是世界上最常见的恶性肿瘤之一。它被认为主要影响老年人，通常被认为是50岁或以上的人。最近的趋势表明，50岁以下患者的结直肠癌，即早发性结直肠癌（EOCRC），呈上升趋势，而在许多地方，老年人群的发病率持平甚至下降。这一令人震惊的趋势在全球范围内得到了描述，高度发达国家与EOCRC疾病负担之间存在明确的关系。更多的颗粒状疾病驱动因素仍然难以捉摸，但与饮食、生活方式、遗传易感性和环境暴露有关。EOCRC的临床、遗传和组织学特征表明，在老年人群中，它是一种独立于CRC的肿瘤实体。全球EOCRC管理面临的挑战包括标准化临床指导、诊断共识和治疗策略。医疗方面的进步提高了公众意识和疾病风险预测。全球EOCRC趋势的模式代表了一个重要的人口健康问题，因此值得临床医生、患者和公众的更多关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Global perspectives on young-onset colorectal cancer: epidemiology, challenges, and advances

Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. It is thought to mainly affect older populations, typically considered those aged 50 or above. Recent trends have shown that CRC in patients younger than 50 years old, known as early onset colorectal cancer (EOCRC), is on the rise while rates of disease in older populations have leveled off or even decreased in many places. This alarming trend is described globally, with a clear relationship between highly developed nations and EOCRC disease burden. More granular disease drivers remain elusive but have been linked to diet, lifestyle, genetic predispositions, and environmental exposure. The clinical, genetic, and histological characteristics of EOCRC imply it is a separate oncologic entity from CRC within older populations. Challenges in management of global EOCRC include standardized clinical guidance, diagnostic consensus, and treatment strategies. Advancements in care have allowed for improved public awareness and disease risk prediction. The pattern of global EOCRC trends represents a significant population health concern, and as such deserves increased attention from clinicians, patients, and the public alike.

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来源期刊

Seminars in Colon and Rectal Surgery SURGERY-

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Seminars in Colon and Rectal Surgery offers a comprehensive and coordinated review of a single, timely topic related to the diagnosis and treatment of proctologic diseases. Each issue is an organized compendium of practical information that serves as a lasting reference for colorectal surgeons, general surgeons, surgeons in training and their colleagues in medicine with an interest in colorectal disorders.